Optimal control theory as a method for designing multidrug adaptive therapy regimens.

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Title: Optimal control theory as a method for designing multidrug adaptive therapy regimens.
Authors: Widdershins A; Penn State College of Medicine, Hershey, PA, USA., Hansen E; Huck Institutes of the Life Sciences, Pennsylvania State University, State College, PA, USA., Read A; Huck Institutes of the Life Sciences, Pennsylvania State University, State College, PA, USA., Hohl R; Penn State College of Medicine, Hershey, PA, USA. rhohl@pennstatehealth.psu.edu.
Source: NPJ systems biology and applications [NPJ Syst Biol Appl] 2026 Feb 14; Vol. 12 (1), pp. 27. Date of Electronic Publication: 2026 Feb 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7189 (Electronic) Linking ISSN: 20567189 NLM ISO Abbreviation: NPJ Syst Biol Appl Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Widdershins+A%22">Widdershins A</searchLink>; Penn State College of Medicine, Hershey, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+E%22">Hansen E</searchLink>; Huck Institutes of the Life Sciences, Pennsylvania State University, State College, PA, USA.<br /><searchLink fieldCode="AU" term="%22Read+A%22">Read A</searchLink>; Huck Institutes of the Life Sciences, Pennsylvania State University, State College, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hohl+R%22">Hohl R</searchLink>; Penn State College of Medicine, Hershey, PA, USA. rhohl@pennstatehealth.psu.edu.
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  Data: <searchLink fieldCode="JN" term="%22101677786%22">NPJ systems biology and applications</searchLink> [NPJ Syst Biol Appl] 2026 Feb 14; Vol. 12 (1), pp. 27. <i>Date of Electronic Publication: </i>2026 Feb 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+in+partnership+with+SBI%2C+The+Systems+Biology+Institute%22">Nature Publishing Group in partnership with SBI, The Systems Biology Institute </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101677786 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2056-7189 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220567189%22">20567189 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Syst Biol Appl <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 14
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