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Pharmacokinetics, Disposition, and Biotransformation of Laroprovstat in Humans: In Vivo and In Vitro Evaluations.

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Title: Pharmacokinetics, Disposition, and Biotransformation of Laroprovstat in Humans: In Vivo and In Vitro Evaluations.
Authors: Li XQ; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Elebring M; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Heijer M; Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Vega R; Translational Sciences and Clinical Development, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Rudvik A; Biometrics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Singh N; Quotient Sciences, Nottingham, UK., Simmonds R; Pharmaron UK Ltd, Rushden, UK., Pelay-Gimeno M; TNO, Leiden, The Netherlands., Reinen J; TNO, Leiden, The Netherlands., Vedin-Nilsson C; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Karlsson IB; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Tanner L; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Panduga V; Clinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Nilsson C; Clinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Rosenmeier J; Translational Sciences and Clinical Development, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, Gothenburg, Sweden., Barbour AM; Clinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gaithersburg, MD, USA.
Source: Journal of clinical pharmacology [J Clin Pharmacol] 2026 Feb; Vol. 66 (2), pp. e70162.
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacokinetics, Disposition, and Biotransformation of Laroprovstat in Humans: In Vivo and In Vitro Evaluations.
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  Data: <searchLink fieldCode="AU" term="%22Li+XQ%22">Li XQ</searchLink>; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Elebring+M%22">Elebring M</searchLink>; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Heijer+M%22">Heijer M</searchLink>; Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Vega+R%22">Vega R</searchLink>; Translational Sciences and Clinical Development, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rudvik+A%22">Rudvik A</searchLink>; Biometrics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Singh+N%22">Singh N</searchLink>; Quotient Sciences, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Simmonds+R%22">Simmonds R</searchLink>; Pharmaron UK Ltd, Rushden, UK.<br /><searchLink fieldCode="AU" term="%22Pelay-Gimeno+M%22">Pelay-Gimeno M</searchLink>; TNO, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Reinen+J%22">Reinen J</searchLink>; TNO, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vedin-Nilsson+C%22">Vedin-Nilsson C</searchLink>; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Karlsson+IB%22">Karlsson IB</searchLink>; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Tanner+L%22">Tanner L</searchLink>; DMPK & BBA, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Panduga+V%22">Panduga V</searchLink>; Clinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Nilsson+C%22">Nilsson C</searchLink>; Clinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Rosenmeier+J%22">Rosenmeier J</searchLink>; Translational Sciences and Clinical Development, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Barbour+AM%22">Barbour AM</searchLink>; Clinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gaithersburg, MD, USA.
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              Text: 2026 Feb
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