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A multi-strain probiotic modulates gut microbiome composition, intestinal barrier integrity and inflammation in a multi-compartmental in vitro gut model of decompensated advanced chronic liver disease.

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Title: A multi-strain probiotic modulates gut microbiome composition, intestinal barrier integrity and inflammation in a multi-compartmental in vitro gut model of decompensated advanced chronic liver disease.
Authors: Maxan ME; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK., Moens F; ProDigest BV, Technologiepark 82, 9052 Ghent, Belgium., Marzorati M; ProDigest BV, Technologiepark 82, 9052 Ghent, Belgium., Mohamad M; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK., Yue C; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK., Said J; Cernotas Ltd, Sandy Farm, The Sands, Farnham, Surrey GU10 1PX, UK., Basit AW; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK., Gaisford S; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK., Patel VC; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK. Electronic address: vish.patel@kcl.ac.uk.
Source: International journal of pharmaceutics [Int J Pharm] 2026 Mar 25; Vol. 693, pp. 126678. Date of Electronic Publication: 2026 Feb 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A multi-strain probiotic modulates gut microbiome composition, intestinal barrier integrity and inflammation in a multi-compartmental in vitro gut model of decompensated advanced chronic liver disease.
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  Data: <searchLink fieldCode="AU" term="%22Maxan+ME%22">Maxan ME</searchLink>; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Moens+F%22">Moens F</searchLink>; ProDigest BV, Technologiepark 82, 9052 Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Marzorati+M%22">Marzorati M</searchLink>; ProDigest BV, Technologiepark 82, 9052 Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Mohamad+M%22">Mohamad M</searchLink>; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Yue+C%22">Yue C</searchLink>; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Said+J%22">Said J</searchLink>; Cernotas Ltd, Sandy Farm, The Sands, Farnham, Surrey GU10 1PX, UK.<br /><searchLink fieldCode="AU" term="%22Basit+AW%22">Basit AW</searchLink>; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.<br /><searchLink fieldCode="AU" term="%22Gaisford+S%22">Gaisford S</searchLink>; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.<br /><searchLink fieldCode="AU" term="%22Patel+VC%22">Patel VC</searchLink>; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Foundation for Liver Research and King's College Hospital, London, UK. Electronic address: vish.patel@kcl.ac.uk.
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              Text: 2026 Mar 25
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