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Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Nav1.5.

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Title: Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Nav1.5.
Authors: Biswas R; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA., López-Serrano AL; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Purohit A; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Ramirez-Navarro A; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA., Huang HL; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA., Cheng X; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.; Translational Data Analytics Institute (TDAI), The Ohio State University, Columbus, OH, USA., Heissler SM; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA., Deschênes I; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA. isabelle.deschenes@osumc.edu.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA. isabelle.deschenes@osumc.edu., Chinthalapudi K; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA. krishna.chinthalapudi@osumc.edu.
Source: Nature communications [Nat Commun] 2026 Feb 16; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Biswas+R%22">Biswas R</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22López-Serrano+AL%22">López-Serrano AL</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Purohit+A%22">Purohit A</searchLink>; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez-Navarro+A%22">Ramirez-Navarro A</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Huang+HL%22">Huang HL</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.; Translational Data Analytics Institute (TDAI), The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Heissler+SM%22">Heissler SM</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Deschênes+I%22">Deschênes I</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA. isabelle.deschenes@osumc.edu.; Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA. isabelle.deschenes@osumc.edu.<br /><searchLink fieldCode="AU" term="%22Chinthalapudi+K%22">Chinthalapudi K</searchLink>; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA. krishna.chinthalapudi@osumc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Feb 16; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Feb 16.
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              Text: 2026 Feb 16
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