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Synaptic and cytoskeletal CSF signatures of motor neuron disease: the role of cyclase-associated protein 2.

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Title: Synaptic and cytoskeletal CSF signatures of motor neuron disease: the role of cyclase-associated protein 2.
Authors: Pilotto A; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy. pilottoandreae@gmail.com.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy. pilottoandreae@gmail.com.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy. pilottoandreae@gmail.com.; Laboratory of Digital Neurology and Biosensors, University of Brescia, Brescia, Italy. pilottoandreae@gmail.com.; Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stokholm, Sweden. pilottoandreae@gmail.com., Pelucchi S; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy., Trasciatti C; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.; Laboratory of Digital Neurology and Biosensors, University of Brescia, Brescia, Italy., Ferullo L; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy., Poli L; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy., Tolassi C; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy., Catanese A; Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Aachen, Aachen, Germany., Girotto I; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy., Labella B; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy., Gorla F; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy., D'Andrea L; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy., Stringhi R; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy., Di Luca M; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy., Marcello E; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy., Padovani A; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.; Laboratory of Digital Neurology and Biosensors, University of Brescia, Brescia, Italy.; Brain Health Center, University of Brescia, Brescia, Italy.
Source: Scientific reports [Sci Rep] 2026 Feb 16; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synaptic and cytoskeletal CSF signatures of motor neuron disease: the role of cyclase-associated protein 2.
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  Data: <searchLink fieldCode="AU" term="%22Pilotto+A%22">Pilotto A</searchLink>; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy. pilottoandreae@gmail.com.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy. pilottoandreae@gmail.com.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy. pilottoandreae@gmail.com.; Laboratory of Digital Neurology and Biosensors, University of Brescia, Brescia, Italy. pilottoandreae@gmail.com.; Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stokholm, Sweden. pilottoandreae@gmail.com.<br /><searchLink fieldCode="AU" term="%22Pelucchi+S%22">Pelucchi S</searchLink>; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Trasciatti+C%22">Trasciatti C</searchLink>; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.; Laboratory of Digital Neurology and Biosensors, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Ferullo+L%22">Ferullo L</searchLink>; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Poli+L%22">Poli L</searchLink>; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Tolassi+C%22">Tolassi C</searchLink>; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Catanese+A%22">Catanese A</searchLink>; Institute of Anatomy and Cell Biology, University of Ulm, 89081, Ulm, Germany.; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Girotto+I%22">Girotto I</searchLink>; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Labella+B%22">Labella B</searchLink>; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Gorla+F%22">Gorla F</searchLink>; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22D'Andrea+L%22">D'Andrea L</searchLink>; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Stringhi+R%22">Stringhi R</searchLink>; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Luca+M%22">Di Luca M</searchLink>; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marcello+E%22">Marcello E</searchLink>; Department of Pharmacological and Biomolecular Sciences, 'Rodolfo Paoletti', University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Padovani+A%22">Padovani A</searchLink>; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.; Neurobiorepository and Laboratory of Advanced Biological Markers, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.; Laboratory of Digital Neurology and Biosensors, University of Brescia, Brescia, Italy.; Brain Health Center, University of Brescia, Brescia, Italy.
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