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Metabolic Reprogramming and GM-CSF Secretion in Areca Nut-Activated Fibroblasts Drive Oral Precancer Progression.

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Title: Metabolic Reprogramming and GM-CSF Secretion in Areca Nut-Activated Fibroblasts Drive Oral Precancer Progression.
Authors: Wang YY; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan., Su CW; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Tseng CH; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Chen PY; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Nguyen HDH; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Chan LP; Cohort Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Chen YK; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Jiang SS; National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan., Lo S; Canniesburn Regional Plastic Surgery and Burns Unit, Glasgow, UK.; G4 0SF, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Yuan SF; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Department of Biological Science and Technology, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Source: Oral diseases [Oral Dis] 2026 Feb 17. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wang+YY%22">Wang YY</searchLink>; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+CW%22">Su CW</searchLink>; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+CH%22">Tseng CH</searchLink>; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PY%22">Chen PY</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nguyen+HDH%22">Nguyen HDH</searchLink>; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chan+LP%22">Chan LP</searchLink>; Cohort Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YK%22">Chen YK</searchLink>; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jiang+SS%22">Jiang SS</searchLink>; National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lo+S%22">Lo S</searchLink>; Canniesburn Regional Plastic Surgery and Burns Unit, Glasgow, UK.; G4 0SF, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Yuan+SF%22">Yuan SF</searchLink>; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Department of Biological Science and Technology, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
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              Text: 2026 Feb 17
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