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The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G2/M arrest and a splicing defect.

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Title: The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G2/M arrest and a splicing defect.
Authors: Sethiya P; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia., Desmarini D; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia., Bowring B; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia., Dinh H; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia., Cain AK; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia., Parsania C; Cancer & Gene Regulation Laboratory Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.; Centre for Rare Diseases & Gene Therapy Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.; School of Medical Sciences, Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW, Australia., Halliday CL; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.; Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Westmead, NSW., Chen SC; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.; Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Westmead, NSW.; Department of Infectious Diseases, Westmead Hospital, Westmead, NSW, Australia., Hewitt K; Westmead Bioresources Facility and Scientific Platforms, Westmead Institute for Medical Research, Westmead, NSW, Australia., Djordjevic JT; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.; Department of Infectious Diseases, Westmead Hospital, Westmead, NSW, Australia.
Source: Virulence [Virulence] 2026 Dec; Vol. 17 (1), pp. 2629100. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE
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  Data: The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G<subscript>2</subscript>/M arrest and a splicing defect.
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  Data: <searchLink fieldCode="AU" term="%22Sethiya+P%22">Sethiya P</searchLink>; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.<br /><searchLink fieldCode="AU" term="%22Desmarini+D%22">Desmarini D</searchLink>; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.<br /><searchLink fieldCode="AU" term="%22Bowring+B%22">Bowring B</searchLink>; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.<br /><searchLink fieldCode="AU" term="%22Dinh+H%22">Dinh H</searchLink>; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cain+AK%22">Cain AK</searchLink>; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Parsania+C%22">Parsania C</searchLink>; Cancer & Gene Regulation Laboratory Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.; Centre for Rare Diseases & Gene Therapy Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.; School of Medical Sciences, Faculty of Medicine & Health, The University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Halliday+CL%22">Halliday CL</searchLink>; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.; Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Westmead, NSW.<br /><searchLink fieldCode="AU" term="%22Chen+SC%22">Chen SC</searchLink>; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.; Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Westmead, NSW.; Department of Infectious Diseases, Westmead Hospital, Westmead, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hewitt+K%22">Hewitt K</searchLink>; Westmead Bioresources Facility and Scientific Platforms, Westmead Institute for Medical Research, Westmead, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Djordjevic+JT%22">Djordjevic JT</searchLink>; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW , Australia.; Sydney Institute for Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW , Australia.; Department of Infectious Diseases, Westmead Hospital, Westmead, NSW, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101531386%22">Virulence</searchLink> [Virulence] 2026 Dec; Vol. 17 (1), pp. 2629100. <i>Date of Electronic Publication: </i>2026 Feb 17.
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              Text: 2026 Dec
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