Modulation of skin inflammation by a recombinant Brown spider venom phospholipase D: In silico and in vitro approaches.

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Title: Modulation of skin inflammation by a recombinant Brown spider venom phospholipase D: In silico and in vitro approaches.
Authors: Schluga PHC; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil., Boia-Ferreira M; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil., Theodoro JL; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil., de Fraga-Ferreira ME; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil., Schemczssen-Graeff Z; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil., Senff-Ribeiro A; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil., Vargas JE; Laboratory of Inflammatory and Neoplastic Cells, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil., Sanches Veiga S; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil., Gremski LH; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil. Electronic address: luizagremski@ufpr.br.
Source: Advances in biological regulation [Adv Biol Regul] 2026 May; Vol. 100, pp. 101160. Date of Electronic Publication: 2026 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101572336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-4934 (Electronic) Linking ISSN: 22124926 NLM ISO Abbreviation: Adv Biol Regul Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Schluga+PHC%22">Schluga PHC</searchLink>; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Boia-Ferreira+M%22">Boia-Ferreira M</searchLink>; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Theodoro+JL%22">Theodoro JL</searchLink>; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Fraga-Ferreira+ME%22">de Fraga-Ferreira ME</searchLink>; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Schemczssen-Graeff+Z%22">Schemczssen-Graeff Z</searchLink>; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Senff-Ribeiro+A%22">Senff-Ribeiro A</searchLink>; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Vargas+JE%22">Vargas JE</searchLink>; Laboratory of Inflammatory and Neoplastic Cells, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Sanches+Veiga+S%22">Sanches Veiga S</searchLink>; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Gremski+LH%22">Gremski LH</searchLink>; Laboratory of Extracellular Matrix and Venom Biotechnology, Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, Brazil. Electronic address: luizagremski@ufpr.br.
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              Text: 2026 May
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