Characterising processing conditions that artifactually bias human brain tissue transcriptomes.

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Title: Characterising processing conditions that artifactually bias human brain tissue transcriptomes.
Authors: Yaqubi M; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Thomas M; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Talbot-Martin J; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Mohammadnia A; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Allot A; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Groh AMR; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Fancy N; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Papageorgopoulou M; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Zhang X; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., McGarry A; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Matthews PM; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Didcot, UK., Petrecca K; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Jackson JS; UK Dementia Research Institute at Imperial College London, London, UK. johanna.jackson@imperial.ac.uk.; Department of Brain Sciences, Imperial College London, London, UK. johanna.jackson@imperial.ac.uk., Stratton JA; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada. jo.stratton@mcgill.ca.
Source: Nature communications [Nat Commun] 2026 Feb 17; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-68872-9