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Characterising processing conditions that artifactually bias human brain tissue transcriptomes.

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Title: Characterising processing conditions that artifactually bias human brain tissue transcriptomes.
Authors: Yaqubi M; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Thomas M; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Talbot-Martin J; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Mohammadnia A; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Allot A; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Groh AMR; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Fancy N; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Papageorgopoulou M; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Zhang X; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., McGarry A; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Matthews PM; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Didcot, UK., Petrecca K; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Jackson JS; UK Dementia Research Institute at Imperial College London, London, UK. johanna.jackson@imperial.ac.uk.; Department of Brain Sciences, Imperial College London, London, UK. johanna.jackson@imperial.ac.uk., Stratton JA; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada. jo.stratton@mcgill.ca.
Source: Nature communications [Nat Commun] 2026 Feb 17; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Yaqubi+M%22">Yaqubi M</searchLink>; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Thomas+M%22">Thomas M</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Talbot-Martin+J%22">Talbot-Martin J</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mohammadnia+A%22">Mohammadnia A</searchLink>; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Allot+A%22">Allot A</searchLink>; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Groh+AMR%22">Groh AMR</searchLink>; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Fancy+N%22">Fancy N</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Papageorgopoulou+M%22">Papageorgopoulou M</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McGarry+A%22">McGarry A</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+PM%22">Matthews PM</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Didcot, UK.<br /><searchLink fieldCode="AU" term="%22Petrecca+K%22">Petrecca K</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Jackson+JS%22">Jackson JS</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK. johanna.jackson@imperial.ac.uk.; Department of Brain Sciences, Imperial College London, London, UK. johanna.jackson@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Stratton+JA%22">Stratton JA</searchLink>; Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada. jo.stratton@mcgill.ca.
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