Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.

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Title: Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.
Authors: Curtabbi A; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain., Jaroszewicz SN; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain., Sanz-Cortés R; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain., Acín-Pérez R; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Prymidis D; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Cherevatenko M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Martínez-de-Mena R; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Esteban-Amo MJ; Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.; Unit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain., de la Fuente MA; Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.; Unit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain., Frezza C; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.; University of Cologne, Faculty of Mathematics and Natural Sciences, Institute for Genetics, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Enríquez JA; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain. jaenriquez@cnic.es.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain. jaenriquez@cnic.es.
Source: Nature metabolism [Nat Metab] 2026 Feb; Vol. 8 (2), pp. 454-466. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2522-5812
DOI:10.1038/s42255-026-01454-7