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Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.

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Title: Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.
Authors: Curtabbi A; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain., Jaroszewicz SN; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain., Sanz-Cortés R; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain., Acín-Pérez R; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Prymidis D; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Cherevatenko M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Martínez-de-Mena R; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Esteban-Amo MJ; Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.; Unit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain., de la Fuente MA; Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.; Unit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain., Frezza C; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.; University of Cologne, Faculty of Mathematics and Natural Sciences, Institute for Genetics, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Enríquez JA; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain. jaenriquez@cnic.es.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain. jaenriquez@cnic.es.
Source: Nature metabolism [Nat Metab] 2026 Feb; Vol. 8 (2), pp. 454-466. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.
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  Data: <searchLink fieldCode="AU" term="%22Curtabbi+A%22">Curtabbi A</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jaroszewicz+SN%22">Jaroszewicz SN</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz-Cortés+R%22">Sanz-Cortés R</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Acín-Pérez+R%22">Acín-Pérez R</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Prymidis+D%22">Prymidis D</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Cherevatenko+M%22">Cherevatenko M</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Martínez-de-Mena+R%22">Martínez-de-Mena R</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Esteban-Amo+MJ%22">Esteban-Amo MJ</searchLink>; Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.; Unit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22de+la+Fuente+MA%22">de la Fuente MA</searchLink>; Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.; Unit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Frezza+C%22">Frezza C</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.; University of Cologne, Faculty of Mathematics and Natural Sciences, Institute for Genetics, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Enríquez+JA%22">Enríquez JA</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain. jaenriquez@cnic.es.; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain. jaenriquez@cnic.es.
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  Data: <searchLink fieldCode="JN" term="%22101736592%22">Nature metabolism</searchLink> [Nat Metab] 2026 Feb; Vol. 8 (2), pp. 454-466. <i>Date of Electronic Publication: </i>2026 Feb 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101736592 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2522-5812 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225225812%22">25225812 </searchLink><i>NLM ISO Abbreviation: </i>Nat Metab <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb
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