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Ameliorative effect of Tiron against paraquat-induced cerebral and pulmonary injury in rats: involvement of ferroptosis, TLR4/NF-κB and Nrf2/HO-1 signaling pathways.

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Title: Ameliorative effect of Tiron against paraquat-induced cerebral and pulmonary injury in rats: involvement of ferroptosis, TLR4/NF-κB and Nrf2/HO-1 signaling pathways.
Authors: Elemam NM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt., Nader MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt., Abdelmageed ME; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. marwaelsayed90@mans.edu.eg.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt. marwaelsayed90@mans.edu.eg.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 May; Vol. 399 (8), pp. 11431-11451. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ameliorative effect of Tiron against paraquat-induced cerebral and pulmonary injury in rats: involvement of ferroptosis, TLR4/NF-κB and Nrf2/HO-1 signaling pathways.
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  Data: <searchLink fieldCode="AU" term="%22Elemam+NM%22">Elemam NM</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt.<br /><searchLink fieldCode="AU" term="%22Nader+MA%22">Nader MA</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelmageed+ME%22">Abdelmageed ME</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. marwaelsayed90@mans.edu.eg.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Egypt. marwaelsayed90@mans.edu.eg.
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        Value: 10.1007/s00210-026-05033-1
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              Text: 2026 May
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