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Combined inhibition of the complement component C5 and the TLR-coreceptor CD14 alters the posttraumatic response in fracture hematoma in a porcine polytrauma model.

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Title: Combined inhibition of the complement component C5 and the TLR-coreceptor CD14 alters the posttraumatic response in fracture hematoma in a porcine polytrauma model.
Authors: Chen D; Experimental Orthopedic and Trauma Surgery, Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany., Nies J; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany., Horst K; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany., Mert Ü; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany., Greven J; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany., Bläsius F; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany., Mollnes TE; Research Laboratory, Nordland Hospital Bodø, Bodø, Norway.; Department of Immunology, Oslo University Hospital, and University of Oslo, Oslo, Norway., Huber-Lang M; Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm, Ulm, Germany., Hildebrand F; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany., van Griensven M; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands., Groven RVM; Experimental Orthopedic and Trauma Surgery, Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands.
Source: Innovative surgical sciences [Innov Surg Sci] 2025 Nov 04; Vol. 11 (1), pp. 65-72. Date of Electronic Publication: 2025 Nov 04 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: De Gruyter Country of Publication: Germany NLM ID: 101708165 Publication Model: eCollection Cited Medium: Internet ISSN: 2364-7485 (Electronic) Linking ISSN: 23647485 NLM ISO Abbreviation: Innov Surg Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Combined inhibition of the complement component C5 and the TLR-coreceptor CD14 alters the posttraumatic response in fracture hematoma in a porcine polytrauma model.
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  Data: <searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Experimental Orthopedic and Trauma Surgery, Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Nies+J%22">Nies J</searchLink>; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Horst+K%22">Horst K</searchLink>; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Mert+Ü%22">Mert Ü</searchLink>; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Greven+J%22">Greven J</searchLink>; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Bläsius+F%22">Bläsius F</searchLink>; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Mollnes+TE%22">Mollnes TE</searchLink>; Research Laboratory, Nordland Hospital Bodø, Bodø, Norway.; Department of Immunology, Oslo University Hospital, and University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Huber-Lang+M%22">Huber-Lang M</searchLink>; Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hildebrand+F%22">Hildebrand F</searchLink>; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22van+Griensven+M%22">van Griensven M</searchLink>; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Groven+RVM%22">Groven RVM</searchLink>; Experimental Orthopedic and Trauma Surgery, Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.; Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101708165%22">Innovative surgical sciences</searchLink> [Innov Surg Sci] 2025 Nov 04; Vol. 11 (1), pp. 65-72. <i>Date of Electronic Publication: </i>2025 Nov 04 (<i>Print Publication: </i>2026).
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