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Cardiomyopathy Gene Variants and Polygenic Risk Scores in Atrial Fibrillation: Evidence for an Atrial-First Phenotype.

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Title: Cardiomyopathy Gene Variants and Polygenic Risk Scores in Atrial Fibrillation: Evidence for an Atrial-First Phenotype.
Authors: da Rocha GL; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada., Feiner J; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Lazarte J; Department of Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada., Pang K; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada., Li Y; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada., Le A; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada., Man A; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Pathan N; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada., Whitlock RP; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada., Belley-Côté EP; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Conen D; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada., Wong JA; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., McIntyre WF; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Healey JS; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Bezzina CR; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Center, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands., Watkins H; Oxford Biomedical Research Centre and Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Ware JS; National Heart and Lung Institute and MRC Laboratory of Medical Sciences, Imperial College London, London, United Kingdom., Tadros R; Cardiovascular Genetics Centre, Montreal Heart Institute and Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Paré G; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada., Roberts JD; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address: jason.roberts@phri.ca.
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2026 Mar 17; Vol. 87 (10), pp. 1279-1299. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22da+Rocha+GL%22">da Rocha GL</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Feiner+J%22">Feiner J</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lazarte+J%22">Lazarte J</searchLink>; Department of Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pang+K%22">Pang K</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Le+A%22">Le A</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Man+A%22">Man A</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pathan+N%22">Pathan N</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Whitlock+RP%22">Whitlock RP</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Belley-Côté+EP%22">Belley-Côté EP</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Conen+D%22">Conen D</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+JA%22">Wong JA</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22McIntyre+WF%22">McIntyre WF</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Healey+JS%22">Healey JS</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bezzina+CR%22">Bezzina CR</searchLink>; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Center, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Watkins+H%22">Watkins H</searchLink>; Oxford Biomedical Research Centre and Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ware+JS%22">Ware JS</searchLink>; National Heart and Lung Institute and MRC Laboratory of Medical Sciences, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tadros+R%22">Tadros R</searchLink>; Cardiovascular Genetics Centre, Montreal Heart Institute and Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Paré+G%22">Paré G</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Roberts+JD%22">Roberts JD</searchLink>; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address: jason.roberts@phri.ca.
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  Data: <searchLink fieldCode="JN" term="%228301365%22">Journal of the American College of Cardiology</searchLink> [J Am Coll Cardiol] 2026 Mar 17; Vol. 87 (10), pp. 1279-1299. <i>Date of Electronic Publication: </i>2026 Feb 18.
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