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Novel antiemetic effect of naldemedine in patients initiating opioids for cancer pain: a secondary analysis of a randomized clinical trial.

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Title: Novel antiemetic effect of naldemedine in patients initiating opioids for cancer pain: a secondary analysis of a randomized clinical trial.
Authors: Higashibata T; Department of Palliative and Supportive Care, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan., Kessoku T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.; Department of Gastroenterology, International University Health and Welfare Graduate School of Medicine, Narita 286-8686, Japan.; Department of Palliative Medicine and Gastroenterology, International University Health and Welfare Narita Hospital, Narita 286-8520, Japan., Kajiura S; Medical Oncology and Palliative Medicine Department, Toyama University Hospital, Toyama 930-0194, Japan., Hirakawa M; Department of Palliative Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan., Oyamada S; Department of Biostatistics, Japanese Organisation for Research and Treatment of Cancer (JORTC) Data Center, Tokyo 116-0013, Japan., Ariyoshi K; Department of Data Management, JORTC Data Center, Tokyo 116-0013, Japan., Yamada T; Tsukuba Clinical Research & Development Organization (T-CReDO), University of Tsukuba, Tsukuba 305-8576, Japan., Yamamoto Y; Department of Gastroenterology, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan., Moriwaki T; Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Kurashiki 710-8602, Japan., Nagaoka H; Department of Palliative Care, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, Japan., Takashima Y; Tsukuba Clinical Research & Development Organization (T-CReDO), University of Tsukuba, Tsukuba 305-8576, Japan., Doki K; Department of Pharmaceutical Sciences, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan., Mathis BJ; Department of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan., Tanaka K; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.; Department of Gastroenterology, International University Health and Welfare Graduate School of Medicine, Narita 286-8686, Japan.; Department of Palliative Medicine and Gastroenterology, International University Health and Welfare Narita Hospital, Narita 286-8520, Japan., Fuyuki A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.; Department of Palliative Care, Shinyurigaoka General Hospital, Kawasaki 215-0026, Japan., Nakajima A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan., Ishihara Y; Department of Palliative Medicine and Gastroenterology, International University Health and Welfare Narita Hospital, Narita 286-8520, Japan., Hayashi R; Medical Oncology and Palliative Medicine Department, Toyama University Hospital, Toyama 930-0194, Japan., Ando T; Third Department of Internal Medicine, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 930-0194, Japan., Kobayashi Y; Department of Pharmacy, St. Marianna University Hospital, Kawasaki 216-8511, Japan., Izawa N; Department of Clinical Oncology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan., Horie Y; Department of Clinical Oncology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan., Morita T; Department of Palliative and Supportive Care, Seirei Mikatahara General Hospital, Hamamatsu 433-8558, Japan.; Research Association for Community Health, Hamamatsu 434-0046, Japan., Hamano J; Department of Palliative and Supportive Care, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Source: The oncologist [Oncologist] 2026 Mar 09; Vol. 31 (4).
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9607837 Publication Model: Print Cited Medium: Internet ISSN: 1549-490X (Electronic) Linking ISSN: 10837159 NLM ISO Abbreviation: Oncologist Subsets: MEDLINE
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  Data: Novel antiemetic effect of naldemedine in patients initiating opioids for cancer pain: a secondary analysis of a randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Higashibata+T%22">Higashibata T</searchLink>; Department of Palliative and Supportive Care, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Kessoku+T%22">Kessoku T</searchLink>; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.; Department of Gastroenterology, International University Health and Welfare Graduate School of Medicine, Narita 286-8686, Japan.; Department of Palliative Medicine and Gastroenterology, International University Health and Welfare Narita Hospital, Narita 286-8520, Japan.<br /><searchLink fieldCode="AU" term="%22Kajiura+S%22">Kajiura S</searchLink>; Medical Oncology and Palliative Medicine Department, Toyama University Hospital, Toyama 930-0194, Japan.<br /><searchLink fieldCode="AU" term="%22Hirakawa+M%22">Hirakawa M</searchLink>; Department of Palliative Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.<br /><searchLink fieldCode="AU" term="%22Oyamada+S%22">Oyamada S</searchLink>; Department of Biostatistics, Japanese Organisation for Research and Treatment of Cancer (JORTC) Data Center, Tokyo 116-0013, Japan.<br /><searchLink fieldCode="AU" term="%22Ariyoshi+K%22">Ariyoshi K</searchLink>; Department of Data Management, JORTC Data Center, Tokyo 116-0013, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+T%22">Yamada T</searchLink>; Tsukuba Clinical Research & Development Organization (T-CReDO), University of Tsukuba, Tsukuba 305-8576, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+Y%22">Yamamoto Y</searchLink>; Department of Gastroenterology, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Moriwaki+T%22">Moriwaki T</searchLink>; Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Kurashiki 710-8602, Japan.<br /><searchLink fieldCode="AU" term="%22Nagaoka+H%22">Nagaoka H</searchLink>; Department of Palliative Care, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Takashima+Y%22">Takashima Y</searchLink>; Tsukuba Clinical Research & Development Organization (T-CReDO), University of Tsukuba, Tsukuba 305-8576, Japan.<br /><searchLink fieldCode="AU" term="%22Doki+K%22">Doki K</searchLink>; Department of Pharmaceutical Sciences, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Mathis+BJ%22">Mathis BJ</searchLink>; Department of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+K%22">Tanaka K</searchLink>; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.; Department of Gastroenterology, International University Health and Welfare Graduate School of Medicine, Narita 286-8686, Japan.; Department of Palliative Medicine and Gastroenterology, International University Health and Welfare Narita Hospital, Narita 286-8520, Japan.<br /><searchLink fieldCode="AU" term="%22Fuyuki+A%22">Fuyuki A</searchLink>; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.; Department of Palliative Care, Shinyurigaoka General Hospital, Kawasaki 215-0026, Japan.<br /><searchLink fieldCode="AU" term="%22Nakajima+A%22">Nakajima A</searchLink>; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.<br /><searchLink fieldCode="AU" term="%22Ishihara+Y%22">Ishihara Y</searchLink>; Department of Palliative Medicine and Gastroenterology, International University Health and Welfare Narita Hospital, Narita 286-8520, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashi+R%22">Hayashi R</searchLink>; Medical Oncology and Palliative Medicine Department, Toyama University Hospital, Toyama 930-0194, Japan.<br /><searchLink fieldCode="AU" term="%22Ando+T%22">Ando T</searchLink>; Third Department of Internal Medicine, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 930-0194, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+Y%22">Kobayashi Y</searchLink>; Department of Pharmacy, St. Marianna University Hospital, Kawasaki 216-8511, Japan.<br /><searchLink fieldCode="AU" term="%22Izawa+N%22">Izawa N</searchLink>; Department of Clinical Oncology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.<br /><searchLink fieldCode="AU" term="%22Horie+Y%22">Horie Y</searchLink>; Department of Clinical Oncology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.<br /><searchLink fieldCode="AU" term="%22Morita+T%22">Morita T</searchLink>; Department of Palliative and Supportive Care, Seirei Mikatahara General Hospital, Hamamatsu 433-8558, Japan.; Research Association for Community Health, Hamamatsu 434-0046, Japan.<br /><searchLink fieldCode="AU" term="%22Hamano+J%22">Hamano J</searchLink>; Department of Palliative and Supportive Care, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
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  Data: <searchLink fieldCode="JN" term="%229607837%22">The oncologist</searchLink> [Oncologist] 2026 Mar 09; Vol. 31 (4).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607837 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1549-490X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210837159%22">10837159 </searchLink><i>NLM ISO Abbreviation: </i>Oncologist <i>Subsets: </i>MEDLINE
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