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Design, synthesis, and characterization of F-18 sigma-1 receptor radiotracers for Alzheimer disease.

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Title: Design, synthesis, and characterization of F-18 sigma-1 receptor radiotracers for Alzheimer disease.
Authors: Jiang H; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Jadhav SB; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Soda AK; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Zhou W; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Chen H; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Xu S; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Qiu L; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Huang T; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Xing Z; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Zhao L; Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA., Lee JJ; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA., Ni R; Institute for Regenerative Medicine, University of Zurich, Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland; Department of Nuclear Medicine, Inselspital University Hospital Bern, Bern, Switzerland., Wong DF; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Currently at Department of Neurosurgery and Kahlert Institute of Addiction Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Peng G; Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA., Perlmutter JS; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Departments of Neurology, Neuroscience, and Programs in Occupational Therapy and Physical Therapy, Washington University School of Medicine, St Louis, MO, 63110, USA., Benzinger TLS; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA., Tu Z; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA. Electronic address: zhudetu@wustl.edu.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Apr 05; Vol. 307, pp. 118647. Date of Electronic Publication: 2026 Feb 08.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
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  Data: Design, synthesis, and characterization of F-18 sigma-1 receptor radiotracers for Alzheimer disease.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Jadhav+SB%22">Jadhav SB</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Soda+AK%22">Soda AK</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+L%22">Qiu L</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Huang+T%22">Huang T</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Xing+Z%22">Xing Z</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Ni+R%22">Ni R</searchLink>; Institute for Regenerative Medicine, University of Zurich, Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland; Department of Nuclear Medicine, Inselspital University Hospital Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wong+DF%22">Wong DF</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Currently at Department of Neurosurgery and Kahlert Institute of Addiction Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Peng+G%22">Peng G</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Perlmutter+JS%22">Perlmutter JS</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Departments of Neurology, Neuroscience, and Programs in Occupational Therapy and Physical Therapy, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Benzinger+TLS%22">Benzinger TLS</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Tu+Z%22">Tu Z</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA. Electronic address: zhudetu@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Apr 05; Vol. 307, pp. 118647. <i>Date of Electronic Publication: </i>2026 Feb 08.
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