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DeCAF defines clinical fibroblast subtypes and multidimensional tumor-stroma crosstalk shaping prognosis and immunotherapy response.

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Title: DeCAF defines clinical fibroblast subtypes and multidimensional tumor-stroma crosstalk shaping prognosis and immunotherapy response.
Authors: Peng XL; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: laura.peng@med.unc.edu., McCabe IC; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kharitonova EV; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Xu Y; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zhao RT; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Luan C; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kearney JF; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kren NP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hariharan A; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lee JJ; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Su J; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Chan PS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Morrison AB; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., LaBella ME; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Herera Loeza SG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cliff A; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kim HJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Pylayeva-Gupta Y; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Tsai S; Department of Surgery, Ohio State University Medical Center, Columbus, OH 43210, USA., Belt BA; Department of Surgery, University of Rochester, Rochester, NY 14642, USA., Panni RZ; Department of Surgery, Washington University in St. Louis, St. Louis, MO 63110, USA., Linehan DC; Department of Surgery, University of Rochester, Rochester, NY 14642, USA., Gomez SM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Damrauer JS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Iuga AC; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kim WY; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: wykim@med.unc.edu., Rashid NU; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: nur2@email.unc.edu., Yeh JJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: jjyeh@med.unc.edu.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Feb 17; Vol. 7 (2), pp. 102611.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: DeCAF defines clinical fibroblast subtypes and multidimensional tumor-stroma crosstalk shaping prognosis and immunotherapy response.
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  Data: <searchLink fieldCode="AU" term="%22Peng+XL%22">Peng XL</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: laura.peng@med.unc.edu.<br /><searchLink fieldCode="AU" term="%22McCabe+IC%22">McCabe IC</searchLink>; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kharitonova+EV%22">Kharitonova EV</searchLink>; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+RT%22">Zhao RT</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Luan+C%22">Luan C</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kearney+JF%22">Kearney JF</searchLink>; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kren+NP%22">Kren NP</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Hariharan+A%22">Hariharan A</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Su+J%22">Su J</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Chan+PS%22">Chan PS</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Morrison+AB%22">Morrison AB</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22LaBella+ME%22">LaBella ME</searchLink>; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Herera+Loeza+SG%22">Herera Loeza SG</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Cliff+A%22">Cliff A</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kim+HJ%22">Kim HJ</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Pylayeva-Gupta+Y%22">Pylayeva-Gupta Y</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+S%22">Tsai S</searchLink>; Department of Surgery, Ohio State University Medical Center, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Belt+BA%22">Belt BA</searchLink>; Department of Surgery, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Panni+RZ%22">Panni RZ</searchLink>; Department of Surgery, Washington University in St. Louis, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Linehan+DC%22">Linehan DC</searchLink>; Department of Surgery, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Gomez+SM%22">Gomez SM</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Damrauer+JS%22">Damrauer JS</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Iuga+AC%22">Iuga AC</searchLink>; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kim+WY%22">Kim WY</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: wykim@med.unc.edu.<br /><searchLink fieldCode="AU" term="%22Rashid+NU%22">Rashid NU</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: nur2@email.unc.edu.<br /><searchLink fieldCode="AU" term="%22Yeh+JJ%22">Yeh JJ</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: jjyeh@med.unc.edu.
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