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Structural defects in amyloid-β fibrils drive secondary nucleation.

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Title: Structural defects in amyloid-β fibrils drive secondary nucleation.
Authors: Hu J; Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden.; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden., Scheidt T; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg., Thacker D; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Axell E; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden., Stemme E; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden., Łapińska U; Living Systems Institute, University of Exeter, Exeter, Devon, UK., Wennmalm S; Department of Applied Physics, Biophysics Group, SciLifeLab, Royal Institute of Technology-KTH, Solna, Sweden., Meisl G; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK., Curk S; Institute of Science and Technology Austria, Klosterneuburg, Austria., Andreasen M; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Arosio P; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland., Šarić A; Institute of Science and Technology Austria, Klosterneuburg, Austria., Schmit JD; Department of Physics, Kansas State University, Manhattan, USA., Knowles TPJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Cavendish Laboratory, University of Cambridge, Cambridge, UK., Sparr E; Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden., Linse S; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden., Michaels TCT; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland., Dear AJ; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden. alexander.dear@bc.biol.ethz.ch.; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland. alexander.dear@bc.biol.ethz.ch.; Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland. alexander.dear@bc.biol.ethz.ch.
Source: Nature communications [Nat Commun] 2026 Feb 18; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden.; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Scheidt+T%22">Scheidt T</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Thacker+D%22">Thacker D</searchLink>; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Axell+E%22">Axell E</searchLink>; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Stemme+E%22">Stemme E</searchLink>; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Łapińska+U%22">Łapińska U</searchLink>; Living Systems Institute, University of Exeter, Exeter, Devon, UK.<br /><searchLink fieldCode="AU" term="%22Wennmalm+S%22">Wennmalm S</searchLink>; Department of Applied Physics, Biophysics Group, SciLifeLab, Royal Institute of Technology-KTH, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Meisl+G%22">Meisl G</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Curk+S%22">Curk S</searchLink>; Institute of Science and Technology Austria, Klosterneuburg, Austria.<br /><searchLink fieldCode="AU" term="%22Andreasen+M%22">Andreasen M</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Vendruscolo+M%22">Vendruscolo M</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Arosio+P%22">Arosio P</searchLink>; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Šarić+A%22">Šarić A</searchLink>; Institute of Science and Technology Austria, Klosterneuburg, Austria.<br /><searchLink fieldCode="AU" term="%22Schmit+JD%22">Schmit JD</searchLink>; Department of Physics, Kansas State University, Manhattan, USA.<br /><searchLink fieldCode="AU" term="%22Knowles+TPJ%22">Knowles TPJ</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Cavendish Laboratory, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sparr+E%22">Sparr E</searchLink>; Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Linse+S%22">Linse S</searchLink>; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Michaels+TCT%22">Michaels TCT</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dear+AJ%22">Dear AJ</searchLink>; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden. alexander.dear@bc.biol.ethz.ch.; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland. alexander.dear@bc.biol.ethz.ch.; Bringing Materials to Life Initiative, ETH Zurich, Zurich, Switzerland. alexander.dear@bc.biol.ethz.ch.
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