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Integrase anchors viral RNA to the HIV-1 capsid interior.

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Title: Integrase anchors viral RNA to the HIV-1 capsid interior.
Authors: Singer MR; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK., Li Z; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Rey JS; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA., Hope J; Division of Structural Biology, Nuffield Department of Medicine, The University of Oxford, Oxford, UK., Chenavier F; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK., Cook NJ; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK., Punch E; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK., Smith J; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK., Zhou Z; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK., Maslen S; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK., Masino L; Structural Biology Technology Platform, The Francis Crick Institute, London, UK., Nans A; Structural Biology Technology Platform, The Francis Crick Institute, London, UK., Skehel M; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK., Taylor IA; Macromolecular Structure Laboratory, The Francis Crick Institute, London, UK., Zanetti G; Membrane Architecture Laboratory, The Francis Crick Institute, London, UK.; Institute of Structural and Molecular Biology, Birkbeck College, London, UK., Zhang P; Division of Structural Biology, Nuffield Department of Medicine, The University of Oxford, Oxford, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK., Perilla JR; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA. JPerilla@udel.edu., Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Alan_Engelman@dfci.harvard.edu., Cherepanov P; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK. Peter.Cherepanov@crick.ac.uk.; Department of Infectious Disease, Imperial College London, London, UK. Peter.Cherepanov@crick.ac.uk.
Source: Nature [Nature] 2026 Apr; Vol. 652 (8111), pp. 1068-1075. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Integrase anchors viral RNA to the HIV-1 capsid interior.
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  Data: <searchLink fieldCode="AU" term="%22Singer+MR%22">Singer MR</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rey+JS%22">Rey JS</searchLink>; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA.<br /><searchLink fieldCode="AU" term="%22Hope+J%22">Hope J</searchLink>; Division of Structural Biology, Nuffield Department of Medicine, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chenavier+F%22">Chenavier F</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Cook+NJ%22">Cook NJ</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Punch+E%22">Punch E</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Smith+J%22">Smith J</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Maslen+S%22">Maslen S</searchLink>; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Masino+L%22">Masino L</searchLink>; Structural Biology Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Nans+A%22">Nans A</searchLink>; Structural Biology Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Skehel+M%22">Skehel M</searchLink>; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+IA%22">Taylor IA</searchLink>; Macromolecular Structure Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Zanetti+G%22">Zanetti G</searchLink>; Membrane Architecture Laboratory, The Francis Crick Institute, London, UK.; Institute of Structural and Molecular Biology, Birkbeck College, London, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Division of Structural Biology, Nuffield Department of Medicine, The University of Oxford, Oxford, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.<br /><searchLink fieldCode="AU" term="%22Perilla+JR%22">Perilla JR</searchLink>; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA. JPerilla@udel.edu.<br /><searchLink fieldCode="AU" term="%22Engelman+AN%22">Engelman AN</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Alan_Engelman@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Cherepanov+P%22">Cherepanov P</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK. Peter.Cherepanov@crick.ac.uk.; Department of Infectious Disease, Imperial College London, London, UK. Peter.Cherepanov@crick.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Apr; Vol. 652 (8111), pp. 1068-1075. <i>Date of Electronic Publication: </i>2026 Feb 18.
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