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Azithromycin mass drug administration to reduce child mortality in Niger (AVENIR II): a master protocol for a cluster-randomized adaptive platform trial to evaluate community-based health interventions.

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Title: Azithromycin mass drug administration to reduce child mortality in Niger (AVENIR II): a master protocol for a cluster-randomized adaptive platform trial to evaluate community-based health interventions.
Authors: Arzika AM; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger., Amza A; Programme Nationale de Santé Oculaire, Ministère de la Santé Publique, Niamey, Niger., Ousmane S; Centre de Recherche Médicale et Sanitaire, Ministère de la Santé Publique, Niamey, Niger., Maliki R; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger., Almou I; Programme Nationale de Santé Oculaire, Ministère de la Santé Publique, Niamey, Niger., Galo N; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger., Harouna N; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger., Mankara A; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger., Aichatou B; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger., Boubacar O; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger., Lebas E; Francis I. Proctor Foundation, University of California, San Francisco, USA., Peterson B; Francis I. Proctor Foundation, University of California, San Francisco, USA., Brandt C; Francis I. Proctor Foundation, University of California, San Francisco, USA., Picariello A; Francis I. Proctor Foundation, University of California, San Francisco, USA., Cheng A; Francis I. Proctor Foundation, University of California, San Francisco, USA., Porco TC; Francis I. Proctor Foundation, University of California, San Francisco, USA.; Department of Ophthalmology, University of California, San Francisco, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA., Doan T; Francis I. Proctor Foundation, University of California, San Francisco, USA.; Department of Ophthalmology, University of California, San Francisco, USA., Arnold BF; Francis I. Proctor Foundation, University of California, San Francisco, USA.; Department of Ophthalmology, University of California, San Francisco, USA.; Institute for Global Health Sciences, University of California, San Francisco, USA., Lietman TM; Francis I. Proctor Foundation, University of California, San Francisco, USA.; Department of Ophthalmology, University of California, San Francisco, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA.; Institute for Global Health Sciences, University of California, San Francisco, USA., O'Brien KS; Francis I. Proctor Foundation, University of California, San Francisco, USA. kieran.obrien@ucsf.edu.; Department of Ophthalmology, University of California, San Francisco, USA. kieran.obrien@ucsf.edu.; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. kieran.obrien@ucsf.edu.; Institute for Global Health Sciences, University of California, San Francisco, USA. kieran.obrien@ucsf.edu.
Source: Trials [Trials] 2026 Feb 18; Vol. 27 (1). Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Azithromycin mass drug administration to reduce child mortality in Niger (AVENIR II): a master protocol for a cluster-randomized adaptive platform trial to evaluate community-based health interventions.
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  Data: <searchLink fieldCode="AU" term="%22Arzika+AM%22">Arzika AM</searchLink>; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger.<br /><searchLink fieldCode="AU" term="%22Amza+A%22">Amza A</searchLink>; Programme Nationale de Santé Oculaire, Ministère de la Santé Publique, Niamey, Niger.<br /><searchLink fieldCode="AU" term="%22Ousmane+S%22">Ousmane S</searchLink>; Centre de Recherche Médicale et Sanitaire, Ministère de la Santé Publique, Niamey, Niger.<br /><searchLink fieldCode="AU" term="%22Maliki+R%22">Maliki R</searchLink>; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger.<br /><searchLink fieldCode="AU" term="%22Almou+I%22">Almou I</searchLink>; Programme Nationale de Santé Oculaire, Ministère de la Santé Publique, Niamey, Niger.<br /><searchLink fieldCode="AU" term="%22Galo+N%22">Galo N</searchLink>; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger.<br /><searchLink fieldCode="AU" term="%22Harouna+N%22">Harouna N</searchLink>; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger.<br /><searchLink fieldCode="AU" term="%22Mankara+A%22">Mankara A</searchLink>; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger.<br /><searchLink fieldCode="AU" term="%22Aichatou+B%22">Aichatou B</searchLink>; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger.<br /><searchLink fieldCode="AU" term="%22Boubacar+O%22">Boubacar O</searchLink>; Centre de Recherche et Interventions en Santé Publique, Birni N'Gaoure, Niger.<br /><searchLink fieldCode="AU" term="%22Lebas+E%22">Lebas E</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+B%22">Peterson B</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Brandt+C%22">Brandt C</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Picariello+A%22">Picariello A</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+A%22">Cheng A</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Porco+TC%22">Porco TC</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.; Department of Ophthalmology, University of California, San Francisco, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Doan+T%22">Doan T</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.; Department of Ophthalmology, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+BF%22">Arnold BF</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.; Department of Ophthalmology, University of California, San Francisco, USA.; Institute for Global Health Sciences, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Lietman+TM%22">Lietman TM</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA.; Department of Ophthalmology, University of California, San Francisco, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA.; Institute for Global Health Sciences, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+KS%22">O'Brien KS</searchLink>; Francis I. Proctor Foundation, University of California, San Francisco, USA. kieran.obrien@ucsf.edu.; Department of Ophthalmology, University of California, San Francisco, USA. kieran.obrien@ucsf.edu.; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. kieran.obrien@ucsf.edu.; Institute for Global Health Sciences, University of California, San Francisco, USA. kieran.obrien@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2026 Feb 18; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Feb 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 18
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