The Neuroprotective Effects of Agomelatine in a 3‑Nitropropionic Acid-Induced Rat Model of Huntington's Disease via Brain-Derived Neurotrophic Factor (BDNF)/tropomyosin-Related Kinase Receptor Type B (TrKB)/Phosphoinositide 3‑Kinase (PI3K)/Protein Kinase B (AKT) Activation and Rho-Associated Protein Kinase 1 (ROCK1) Pathway Inhibition.
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| Title: | The Neuroprotective Effects of Agomelatine in a 3‑Nitropropionic Acid-Induced Rat Model of Huntington's Disease via Brain-Derived Neurotrophic Factor (BDNF)/tropomyosin-Related Kinase Receptor Type B (TrKB)/Phosphoinositide 3‑Kinase (PI3K)/Protein Kinase B (AKT) Activation and Rho-Associated Protein Kinase 1 (ROCK1) Pathway Inhibition. |
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| Authors: | Abouzaid HH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Sayed RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.; Department of Clinical Pharmacy, Newgiza University, Giza 12563, Egypt., Wadie W; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Ibrahim WW; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. |
| Source: | ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2026 Feb 02; Vol. 9 (2), pp. 414-429. Date of Electronic Publication: 2026 Feb 02 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41710750 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Neuroprotective Effects of Agomelatine in a 3‑Nitropropionic Acid-Induced Rat Model of Huntington's Disease via Brain-Derived Neurotrophic Factor (BDNF)/tropomyosin-Related Kinase Receptor Type B (TrKB)/Phosphoinositide 3‑Kinase (PI3K)/Protein Kinase B (AKT) Activation and Rho-Associated Protein Kinase 1 (ROCK1) Pathway Inhibition. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Abouzaid+HH%22">Abouzaid HH</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22Sayed+RH%22">Sayed RH</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.; Department of Clinical Pharmacy, Newgiza University, Giza 12563, Egypt.<br /><searchLink fieldCode="AU" term="%22Wadie+W%22">Wadie W</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22Ibrahim+WW%22">Ibrahim WW</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101721411%22">ACS pharmacology & translational science</searchLink> [ACS Pharmacol Transl Sci] 2026 Feb 02; Vol. 9 (2), pp. 414-429. <i>Date of Electronic Publication: </i>2026 Feb 02 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101721411 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2575-9108 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225759108%22">25759108 </searchLink><i>NLM ISO Abbreviation: </i>ACS Pharmacol Transl Sci <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41710750 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acsptsci.5c00721 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 414 Titles: – TitleFull: The Neuroprotective Effects of Agomelatine in a 3‑Nitropropionic Acid-Induced Rat Model of Huntington's Disease via Brain-Derived Neurotrophic Factor (BDNF)/tropomyosin-Related Kinase Receptor Type B (TrKB)/Phosphoinositide 3‑Kinase (PI3K)/Protein Kinase B (AKT) Activation and Rho-Associated Protein Kinase 1 (ROCK1) Pathway Inhibition. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Abouzaid HH – PersonEntity: Name: NameFull: Sayed RH – PersonEntity: Name: NameFull: Wadie W – PersonEntity: Name: NameFull: Ibrahim WW IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 02 Text: 2026 Feb 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2575-9108 Numbering: – Type: volume Value: 9 – Type: issue Value: 2 Titles: – TitleFull: ACS pharmacology & translational science Type: main |
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