T-Cell-Derived Exosomes From Multi Core Granules Exhibit Superior Caspase-3-Mediated Tumor-Suppressive Activity Compared to Those From Multivesicular Bodies.

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Title: T-Cell-Derived Exosomes From Multi Core Granules Exhibit Superior Caspase-3-Mediated Tumor-Suppressive Activity Compared to Those From Multivesicular Bodies.
Authors: Alawar N; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Schirra C; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Rasuli R; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.; Department of Medical Oncology and Hematology, University Hospital of Zürich (USZ), Zürich, Switzerland., Fecher-Trost C; Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany.; Department of Experimental and Clinical Toxicology and Pharmacology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany., Weins L; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.; Department of Hematology and Oncology, Caritas Klinikum Saarbrücken, Saarbrücken, Germany., Meyer MR; Department of Experimental and Clinical Toxicology and Pharmacology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany., Flockerzi V; Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany., Keller A; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarbrücken, Germany.; PharmaScienceHub, Saarbrücken, Germany., Dustin ML; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Rettig J; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Becherer U; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.
Source: Journal of extracellular vesicles [J Extracell Vesicles] 2026 Feb; Vol. 15 (2), pp. e70239.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101610479 Publication Model: Print Cited Medium: Internet ISSN: 2001-3078 (Electronic) Linking ISSN: 20013078 NLM ISO Abbreviation: J Extracell Vesicles Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: T-Cell-Derived Exosomes From Multi Core Granules Exhibit Superior Caspase-3-Mediated Tumor-Suppressive Activity Compared to Those From Multivesicular Bodies.
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  Data: <searchLink fieldCode="AU" term="%22Alawar+N%22">Alawar N</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schirra+C%22">Schirra C</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rasuli+R%22">Rasuli R</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.; Department of Medical Oncology and Hematology, University Hospital of Zürich (USZ), Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fecher-Trost+C%22">Fecher-Trost C</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany.; Department of Experimental and Clinical Toxicology and Pharmacology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Weins+L%22">Weins L</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.; Department of Hematology and Oncology, Caritas Klinikum Saarbrücken, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+MR%22">Meyer MR</searchLink>; Department of Experimental and Clinical Toxicology and Pharmacology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Flockerzi+V%22">Flockerzi V</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Keller+A%22">Keller A</searchLink>; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarbrücken, Germany.; PharmaScienceHub, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Dustin+ML%22">Dustin ML</searchLink>; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rettig+J%22">Rettig J</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Becherer+U%22">Becherer U</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.
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              Text: 2026 Feb
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