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Enhancing IgG fragment crystallizable sialylation improves the therapeutic activity of IL-23 cytokine blockade.

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Title: Enhancing IgG fragment crystallizable sialylation improves the therapeutic activity of IL-23 cytokine blockade.
Authors: Kämpf S; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Hematianlarki M; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Altmann L; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Bright JM; Nuvig Therapeutics Inc., Palo Alto, California, USA., Toda AM; Nuvig Therapeutics Inc., Palo Alto, California, USA., Mirzapoor Z; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Zollner V; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Werner A; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Bulang J; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Radovani B; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Wöhner M; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany., Avery W; Nuvig Therapeutics Inc., Palo Alto, California, USA., Karbarz MJ; Nuvig Therapeutics Inc., Palo Alto, California, USA., Conley PB; Nuvig Therapeutics Inc., Palo Alto, California, USA., Coffey GP; Nuvig Therapeutics Inc., Palo Alto, California, USA., Nimmerjahn F; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.
Source: JCI insight [JCI Insight] 2026 Feb 19; Vol. 11 (7). Date of Electronic Publication: 2026 Feb 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enhancing IgG fragment crystallizable sialylation improves the therapeutic activity of IL-23 cytokine blockade.
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  Data: <searchLink fieldCode="AU" term="%22Kämpf+S%22">Kämpf S</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hematianlarki+M%22">Hematianlarki M</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Altmann+L%22">Altmann L</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bright+JM%22">Bright JM</searchLink>; Nuvig Therapeutics Inc., Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Toda+AM%22">Toda AM</searchLink>; Nuvig Therapeutics Inc., Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Mirzapoor+Z%22">Mirzapoor Z</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zollner+V%22">Zollner V</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Werner+A%22">Werner A</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bulang+J%22">Bulang J</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Radovani+B%22">Radovani B</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wöhner+M%22">Wöhner M</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.<br /><searchLink fieldCode="AU" term="%22Avery+W%22">Avery W</searchLink>; Nuvig Therapeutics Inc., Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Karbarz+MJ%22">Karbarz MJ</searchLink>; Nuvig Therapeutics Inc., Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Conley+PB%22">Conley PB</searchLink>; Nuvig Therapeutics Inc., Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Coffey+GP%22">Coffey GP</searchLink>; Nuvig Therapeutics Inc., Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Nimmerjahn+F%22">Nimmerjahn F</searchLink>; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2026 Feb 19; Vol. 11 (7). <i>Date of Electronic Publication: </i>2026 Feb 19 (<i>Print Publication: </i>2026).
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              Text: 2026 Feb 19
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