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ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia.

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Title: ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia.
Authors: Schäfer S; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany., Rahimian E; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany., Schmitz-Hübsch L; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany., Shaikh M; Laboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic., Brilloff S; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany., Kufrin V; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany., Küchler S; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany., Fedorova M; Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany., Kusebauch N; Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany., Ni Z; Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany., Helm D; Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany., Jeremias I; Department of Pediatrics, Dr. Von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany., Schewe DM; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany., Ball CR; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; TUD Dresden University of Technology, Faculty of Biology, Dresden, Germany., Bornhäuser M; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany., Glimm H; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany; Translational Functional Cancer Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Alberich-Jorda M; Laboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic; Childhood Leukaemia Investigation Prague, Department of Pediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague, University Hospital Motol, Prague, Czech Republic., Bill M; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany., Wurm AA; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany. Electronic address: alexander.wurm@nct-dresden.de.
Source: Cell reports [Cell Rep] 2026 Mar 24; Vol. 45 (3), pp. 117010. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Schäfer+S%22">Schäfer S</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Rahimian+E%22">Rahimian E</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitz-Hübsch+L%22">Schmitz-Hübsch L</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Shaikh+M%22">Shaikh M</searchLink>; Laboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Brilloff+S%22">Brilloff S</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kufrin+V%22">Kufrin V</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Küchler+S%22">Küchler S</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Fedorova+M%22">Fedorova M</searchLink>; Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kusebauch+N%22">Kusebauch N</searchLink>; Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ni+Z%22">Ni Z</searchLink>; Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Helm+D%22">Helm D</searchLink>; Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jeremias+I%22">Jeremias I</searchLink>; Department of Pediatrics, Dr. Von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schewe+DM%22">Schewe DM</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ball+CR%22">Ball CR</searchLink>; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; TUD Dresden University of Technology, Faculty of Biology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bornhäuser+M%22">Bornhäuser M</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Glimm+H%22">Glimm H</searchLink>; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany; Translational Functional Cancer Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Alberich-Jorda+M%22">Alberich-Jorda M</searchLink>; Laboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic; Childhood Leukaemia Investigation Prague, Department of Pediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague, University Hospital Motol, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Bill+M%22">Bill M</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Wurm+AA%22">Wurm AA</searchLink>; Mildred Scheel Early Career Center, National Center for Tumor Diseases (NCT/UCC) Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a Partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany. Electronic address: alexander.wurm@nct-dresden.de.
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