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P2X7R-mediated IL-1β release by human brain tissue: the impact of CNS-penetrant potential therapeutics.

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Title: P2X7R-mediated IL-1β release by human brain tissue: the impact of CNS-penetrant potential therapeutics.
Authors: Cowley J; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Harrison N; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Pegg A; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Chan H; Celentyx Ltd, Birmingham, B15 2SQ, UK., Li Z; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Kaur A; Celentyx Ltd, Birmingham, B15 2SQ, UK., Welsh E; Celentyx Ltd, Birmingham, B15 2SQ, UK., Brewin A; Celentyx Ltd, Birmingham, B15 2SQ, UK., Carlos Yam-Puc J; Celentyx Ltd, Birmingham, B15 2SQ, UK., Fensome G; Celentyx Ltd, Birmingham, B15 2SQ, UK., Broome E; Celentyx Ltd, Birmingham, B15 2SQ, UK., Morano IM; Celentyx Ltd, Birmingham, B15 2SQ, UK., Jinks E; Celentyx Ltd, Birmingham, B15 2SQ, UK., Grafton G; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Cooper AJ; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Ahmed Z; School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Stevens AR; School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK., Anderson FG; School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Wykes V; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.; Department of Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Chelvarajah R; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK., Tsermoulas G; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.; Department of Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Ughratdar I; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK., Zisakis A; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK., O'Halloran PJ; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, D02 HC66, Ireland., Davies DJ; School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK., Land T; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK., Chowdhury YA; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK., Sher Z; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK., Yakoub KM; School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK., Bergin C; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK., Galloway L; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK., Upthegrove R; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.; Institute for Mental Health University of Birmingham, Birmingham, B15 2TT, UK.; Birmingham Early Intervention Service, Birmingham Womens and Childrens NHS Foundation Trust, Birmingham, B15 2TG, UK., Brady CA; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Celentyx Ltd, Birmingham, B15 2SQ, UK., Gordon J; Celentyx Ltd, Birmingham, B15 2SQ, UK., Qureshi O; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Celentyx Ltd, Birmingham, B15 2SQ, UK., Belli A; School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK., Barnes NM; Neuropharmacology Research Group, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK.
Source: Brain : a journal of neurology [Brain] 2026 Feb 19. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
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  Data: P2X7R-mediated IL-1β release by human brain tissue: the impact of CNS-penetrant potential therapeutics.
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Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.<br /><searchLink fieldCode="AU" term="%22O'Halloran+PJ%22">O'Halloran PJ</searchLink>; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, D02 HC66, Ireland.<br /><searchLink fieldCode="AU" term="%22Davies+DJ%22">Davies DJ</searchLink>; School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK.<br /><searchLink fieldCode="AU" term="%22Land+T%22">Land T</searchLink>; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.<br /><searchLink fieldCode="AU" term="%22Chowdhury+YA%22">Chowdhury YA</searchLink>; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.<br /><searchLink fieldCode="AU" term="%22Sher+Z%22">Sher Z</searchLink>; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.<br /><searchLink fieldCode="AU" term="%22Yakoub+KM%22">Yakoub KM</searchLink>; School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK.<br /><searchLink fieldCode="AU" term="%22Bergin+C%22">Bergin C</searchLink>; NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK.<br /><searchLink fieldCode="AU" term="%22Galloway+L%22">Galloway L</searchLink>; Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2QW, UK.<br /><searchLink fieldCode="AU" term="%22Upthegrove+R%22">Upthegrove R</searchLink>; 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