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Rapid directed evolution guided by protein language models and epistatic interactions.

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Title: Rapid directed evolution guided by protein language models and epistatic interactions.
Authors: Tran VQ; Arc Institute, Palo Alto, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA., Nemeth M; Arc Institute, Palo Alto, CA, USA., Bartie LJ; Arc Institute, Palo Alto, CA, USA., Chandrasekaran SS; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; San Francisco Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Fanton A; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; San Francisco Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Moon HC; Arc Institute, Palo Alto, CA, USA., Hie BL; Arc Institute, Palo Alto, CA, USA.; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.; Stanford Data Science, Stanford University, Stanford, CA, USA., Konermann S; Arc Institute, Palo Alto, CA, USA.; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA., Hsu PD; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.
Source: Science (New York, N.Y.) [Science] 2026 May 07; Vol. 392 (6798), pp. eaea1820. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rapid directed evolution guided by protein language models and epistatic interactions.
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  Data: <searchLink fieldCode="AU" term="%22Tran+VQ%22">Tran VQ</searchLink>; Arc Institute, Palo Alto, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nemeth+M%22">Nemeth M</searchLink>; Arc Institute, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bartie+LJ%22">Bartie LJ</searchLink>; Arc Institute, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chandrasekaran+SS%22">Chandrasekaran SS</searchLink>; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; San Francisco Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fanton+A%22">Fanton A</searchLink>; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; San Francisco Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Moon+HC%22">Moon HC</searchLink>; Arc Institute, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hie+BL%22">Hie BL</searchLink>; Arc Institute, Palo Alto, CA, USA.; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.; Stanford Data Science, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Konermann+S%22">Konermann S</searchLink>; Arc Institute, Palo Alto, CA, USA.; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+PD%22">Hsu PD</searchLink>; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 May 07; Vol. 392 (6798), pp. eaea1820. <i>Date of Electronic Publication: </i>2026 May 07.
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        Value: 10.1126/science.aea1820
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              Text: 2026 May 07
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