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Development and validation of a robust UPLC-MS/MS method for the analysis of polyamines in cells, biofluids and tissues.

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Title: Development and validation of a robust UPLC-MS/MS method for the analysis of polyamines in cells, biofluids and tissues.
Authors: Iannone M; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium., Vereyken L; Preclinical Sciences & Translational Safety, Johnson&Johnson, Beerse, Belgium., Grajchen E; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium., Deneubourg C; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium., Gorremans S; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium., Donck LV; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium., Bretteville A; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium., Moechars D; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium., Jahouh F; Preclinical Sciences & Translational Safety, Johnson&Johnson, Beerse, Belgium. Electronic address: fjahouh@its.jnj.com., Vreeken RJ; Maastricht MultiModal Molecular Imaging Institute (M4I), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2026 Jul 15; Vol. 274, pp. 117392. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Development and validation of a robust UPLC-MS/MS method for the analysis of polyamines in cells, biofluids and tissues.
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  Data: <searchLink fieldCode="AU" term="%22Iannone+M%22">Iannone M</searchLink>; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Vereyken+L%22">Vereyken L</searchLink>; Preclinical Sciences & Translational Safety, Johnson&Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Grajchen+E%22">Grajchen E</searchLink>; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Deneubourg+C%22">Deneubourg C</searchLink>; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Gorremans+S%22">Gorremans S</searchLink>; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Donck+LV%22">Donck LV</searchLink>; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Bretteville+A%22">Bretteville A</searchLink>; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Moechars+D%22">Moechars D</searchLink>; Neuroscience Discovery, Johnson&Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Jahouh+F%22">Jahouh F</searchLink>; Preclinical Sciences & Translational Safety, Johnson&Johnson, Beerse, Belgium. Electronic address: fjahouh@its.jnj.com.<br /><searchLink fieldCode="AU" term="%22Vreeken+RJ%22">Vreeken RJ</searchLink>; Maastricht MultiModal Molecular Imaging Institute (M4I), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%228309336%22">Journal of pharmaceutical and biomedical analysis</searchLink> [J Pharm Biomed Anal] 2026 Jul 15; Vol. 274, pp. 117392. <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8309336 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-264X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207317085%22">07317085 </searchLink><i>NLM ISO Abbreviation: </i>J Pharm Biomed Anal <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jpba.2026.117392
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        Text: English
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        StartPage: 117392
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      – TitleFull: Development and validation of a robust UPLC-MS/MS method for the analysis of polyamines in cells, biofluids and tissues.
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              Text: 2026 Jul 15
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