Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac oxidative stress, inflammation, and heart failure development.

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Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac oxidative stress, inflammation, and heart failure development.
Authors: Bhattarai U; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Niu Z; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Pan L; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., He X; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Wang D; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Orman TC; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Wang H; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Zeng H; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Chen JX; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Xu X; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, United States., Speed JS; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Clemmer JS; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Hall JE; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Chen Y; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States. Electronic address: ychen2@umc.edu.
Source: Redox biology [Redox Biol] 2026 Apr; Vol. 91, pp. 104082. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
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  Data: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac oxidative stress, inflammation, and heart failure development.
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  Data: <searchLink fieldCode="AU" term="%22Bhattarai+U%22">Bhattarai U</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Niu+Z%22">Niu Z</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Pan+L%22">Pan L</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Orman+TC%22">Orman TC</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Chen+JX%22">Chen JX</searchLink>; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, United States.<br /><searchLink fieldCode="AU" term="%22Speed+JS%22">Speed JS</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Clemmer+JS%22">Clemmer JS</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Hall+JE%22">Hall JE</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States. Electronic address: ychen2@umc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2026 Apr; Vol. 91, pp. 104082. <i>Date of Electronic Publication: </i>2026 Feb 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101605639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2317 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132317%22">22132317 </searchLink><i>NLM ISO Abbreviation: </i>Redox Biol <i>Subsets: </i>MEDLINE
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