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LSD microdosing for major depressive disorder: Mood and pharmacokinetic outcomes from a Phase 2a trial.

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Title: LSD microdosing for major depressive disorder: Mood and pharmacokinetic outcomes from a Phase 2a trial.
Authors: Daldegan-Bueno D; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: d.daldegan@auckland.ac.nz., Donegan CJ; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22 Park Avenue, Grafton, Auckland 1023, New Zealand. Electronic address: carina.donegan@auckland.ac.nz., Sumner R; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: r.sumner@auckland.ac.nz., Forsyth A; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: a.forsyth@auckland.ac.nz., Jeong SH; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: s.jeong@auckland.ac.nz., Evans W; Mana Health, 7 Ruskin St, Parnell, Auckland 1052, New Zealand. Electronic address: info@manahealth.co.nz., Alshakhouri M; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: malak.alshakhouri@auckland.ac.nz., Murphy RJ; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: robin.murphy@auckland.ac.nz., Reynolds L; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22 Park Avenue, Grafton, Auckland 1023, New Zealand. Electronic address: l.reynolds@auckland.ac.nz., Hoeh N; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22 Park Avenue, Grafton, Auckland 1023, New Zealand. Electronic address: n.hoeh@auckland.ac.nz., Allen N; Department of Computer and Information Sciences, Auckland University of Technology, 6 St Paul Street, Auckland 1010, New Zealand. Electronic address: nathan.allen@aut.ac.nz., Sundram F; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22 Park Avenue, Grafton, Auckland 1023, New Zealand. Electronic address: f.sundram@auckland.ac.nz., Menkes DB; Department of Psychological Medicine, Waikato Clinical Campus, University of Auckland, Pembroke Street, Hamilton 3240, New Zealand. Electronic address: david.menkes@auckland.ac.nz., Muthukumaraswamy S; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: sd.muthu@auckland.ac.nz.
Source: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2026 Mar 20; Vol. 145, pp. 111645. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE
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  Data: LSD microdosing for major depressive disorder: Mood and pharmacokinetic outcomes from a Phase 2a trial.
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  Data: <searchLink fieldCode="AU" term="%22Daldegan-Bueno+D%22">Daldegan-Bueno D</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: d.daldegan@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Donegan+CJ%22">Donegan CJ</searchLink>; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22 Park Avenue, Grafton, Auckland 1023, New Zealand. Electronic address: carina.donegan@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Sumner+R%22">Sumner R</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: r.sumner@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Forsyth+A%22">Forsyth A</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: a.forsyth@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Jeong+SH%22">Jeong SH</searchLink>; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: s.jeong@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Evans+W%22">Evans W</searchLink>; Mana Health, 7 Ruskin St, Parnell, Auckland 1052, New Zealand. Electronic address: info@manahealth.co.nz.<br /><searchLink fieldCode="AU" term="%22Alshakhouri+M%22">Alshakhouri M</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: malak.alshakhouri@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Murphy+RJ%22">Murphy RJ</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: robin.murphy@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Reynolds+L%22">Reynolds L</searchLink>; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22 Park Avenue, Grafton, Auckland 1023, New Zealand. Electronic address: l.reynolds@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Hoeh+N%22">Hoeh N</searchLink>; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22 Park Avenue, Grafton, Auckland 1023, New Zealand. Electronic address: n.hoeh@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Allen+N%22">Allen N</searchLink>; Department of Computer and Information Sciences, Auckland University of Technology, 6 St Paul Street, Auckland 1010, New Zealand. Electronic address: nathan.allen@aut.ac.nz.<br /><searchLink fieldCode="AU" term="%22Sundram+F%22">Sundram F</searchLink>; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22 Park Avenue, Grafton, Auckland 1023, New Zealand. Electronic address: f.sundram@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Menkes+DB%22">Menkes DB</searchLink>; Department of Psychological Medicine, Waikato Clinical Campus, University of Auckland, Pembroke Street, Hamilton 3240, New Zealand. Electronic address: david.menkes@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Muthukumaraswamy+S%22">Muthukumaraswamy S</searchLink>; School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: sd.muthu@auckland.ac.nz.
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