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mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR+/HER2- breast cancer.

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Title: mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR+/HER2- breast cancer.
Authors: von Wichert L; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Stroh A; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Witt M; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Wanzel M; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany., Mernberger M; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany., Griewing S; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Wündisch T; Comprehensive Cancer Center Marburg, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Pfitzner BM; Institute of Pathology, DRK Clinics Westend, Berlin, Germany., Teply-Szymanski J; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Litmeyer AS; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Denkert C; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Wagner U; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany., Stiewe T; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Genomics Core Facility, Philipps-University, Marburg, Germany.; Institute of Lung Health, Justus Liebig University, Gießen, Germany., Gremke N; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany. Gremken@staff.uni-marburg.de.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany. Gremken@staff.uni-marburg.de.
Source: Cell death & disease [Cell Death Dis] 2026 Feb 19; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR<superscript>+</superscript>/HER2<superscript>-</superscript> breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22von+Wichert+L%22">von Wichert L</searchLink>; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Stroh+A%22">Stroh A</searchLink>; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Witt+M%22">Witt M</searchLink>; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wanzel+M%22">Wanzel M</searchLink>; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mernberger+M%22">Mernberger M</searchLink>; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Griewing+S%22">Griewing S</searchLink>; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wündisch+T%22">Wündisch T</searchLink>; Comprehensive Cancer Center Marburg, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Pfitzner+BM%22">Pfitzner BM</searchLink>; Institute of Pathology, DRK Clinics Westend, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Teply-Szymanski+J%22">Teply-Szymanski J</searchLink>; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Litmeyer+AS%22">Litmeyer AS</searchLink>; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Denkert+C%22">Denkert C</searchLink>; Institute of Pathology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+U%22">Wagner U</searchLink>; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Stiewe+T%22">Stiewe T</searchLink>; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.; Genomics Core Facility, Philipps-University, Marburg, Germany.; Institute of Lung Health, Justus Liebig University, Gießen, Germany.<br /><searchLink fieldCode="AU" term="%22Gremke+N%22">Gremke N</searchLink>; Institute of Molecular Oncology, Universities of Gießen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany. Gremken@staff.uni-marburg.de.; Department of Gynecology, Gynecological Endocrinology and Oncology, University Hospital Marburg (UKGM), Philipps-University, Marburg, Germany. Gremken@staff.uni-marburg.de.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Feb 19; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Feb 19.
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