Population Pharmacokinetic/Pharmacodynamic Modeling of Volagidemab, a Glucagon Receptor Antagonist, in Healthy Chinese and US Subjects Following Single Subcutaneous Administration.
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| Title: | Population Pharmacokinetic/Pharmacodynamic Modeling of Volagidemab, a Glucagon Receptor Antagonist, in Healthy Chinese and US Subjects Following Single Subcutaneous Administration. |
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| Authors: | Hu Z; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Zhu M; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Tang L; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Zhu J; State Key Laboratory of Natural Medicine, Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China., Yu F; Beijing YEEDOZENCOM Tech. Ltd., Beijing, 100055, China., Huang H; Beijing YEEDOZENCOM Tech. Ltd., Beijing, 100055, China., Yan H; REMD Biotherapeutics Inc., Camarillo, CA, 93012, USA., Xu R; REMD Biotherapeutics Inc., Camarillo, CA, 93012, USA., He H; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. huahe_cpupk@cpu.edu.cn. |
| Source: | Pharmaceutical research [Pharm Res] 2026 Apr; Vol. 43 (4), pp. 1057-1070. Date of Electronic Publication: 2026 Feb 20. |
| Publication Type: | Clinical Trial, Phase I; Comparative Study; Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41714547 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Population Pharmacokinetic/Pharmacodynamic Modeling of Volagidemab, a Glucagon Receptor Antagonist, in Healthy Chinese and US Subjects Following Single Subcutaneous Administration. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hu+Z%22">Hu Z</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Zhu+M%22">Zhu M</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Tang+L%22">Tang L</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; State Key Laboratory of Natural Medicine, Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Yu+F%22">Yu F</searchLink>; Beijing YEEDOZENCOM Tech. Ltd., Beijing, 100055, China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Beijing YEEDOZENCOM Tech. Ltd., Beijing, 100055, China.<br /><searchLink fieldCode="AU" term="%22Yan+H%22">Yan H</searchLink>; REMD Biotherapeutics Inc., Camarillo, CA, 93012, USA.<br /><searchLink fieldCode="AU" term="%22Xu+R%22">Xu R</searchLink>; REMD Biotherapeutics Inc., Camarillo, CA, 93012, USA.<br /><searchLink fieldCode="AU" term="%22He+H%22">He H</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. huahe&#95;cpupk@cpu.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228406521%22">Pharmaceutical research</searchLink> [Pharm Res] 2026 Apr; Vol. 43 (4), pp. 1057-1070. <i>Date of Electronic Publication: </i>2026 Feb 20. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase I; Comparative Study; Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic%2FPlenum+Publishers%22">Kluwer Academic/Plenum Publishers </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8406521 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-904X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207248741%22">07248741 </searchLink><i>NLM ISO Abbreviation: </i>Pharm Res <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41714547 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11095-026-04028-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1057 Titles: – TitleFull: Population Pharmacokinetic/Pharmacodynamic Modeling of Volagidemab, a Glucagon Receptor Antagonist, in Healthy Chinese and US Subjects Following Single Subcutaneous Administration. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hu Z – PersonEntity: Name: NameFull: Zhu M – PersonEntity: Name: NameFull: Tang L – PersonEntity: Name: NameFull: Zhu J – PersonEntity: Name: NameFull: Yu F – PersonEntity: Name: NameFull: Huang H – PersonEntity: Name: NameFull: Yan H – PersonEntity: Name: NameFull: Xu R – PersonEntity: Name: NameFull: He H IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1573-904X Numbering: – Type: volume Value: 43 – Type: issue Value: 4 Titles: – TitleFull: Pharmaceutical research Type: main |
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