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Creating Engineered NAC Flaps Using in Vivo Revascularization: A Proof-Of-Concept Study.

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Title: Creating Engineered NAC Flaps Using in Vivo Revascularization: A Proof-Of-Concept Study.
Authors: Berkane Y; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. yanis.berkane@chu-rennes.fr.; Shriners Children's Boston, Boston, MA, 02114, USA. yanis.berkane@chu-rennes.fr.; Department of Plastic, Reconstructive and Aesthetic Surgery, CHU de Rennes, University of Rennes, Rennes, 35000, France. yanis.berkane@chu-rennes.fr.; SITI Laboratory, UMR1236, INSERM, Etablissement Francais du Sang, University of Rennes, Rennes, 35000, France. yanis.berkane@chu-rennes.fr., Abaci A; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA., Ellis BW; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA., van Dieren L; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA., Hendi E; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA., Oubari H; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA., Bertheuil N; Department of Plastic, Reconstructive and Aesthetic Surgery, CHU de Rennes, University of Rennes, Rennes, 35000, France.; SITI Laboratory, UMR1236, INSERM, Etablissement Francais du Sang, University of Rennes, Rennes, 35000, France., Oganesyan R; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Cetrulo CL Jr; Shriners Children's Boston, Boston, MA, 02114, USA.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA.; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., McCarthy ME; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of General Surgery, Lahey Hospital and Medical Center, Burlington, MA, 01805, USA., Randolph MA; Shriners Children's Boston, Boston, MA, 02114, USA.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA., Lellouch AG; Shriners Children's Boston, Boston, MA, 02114, USA.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA.; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Innovative Therapies in Hemostasis, INSERM UMR-S 1140, University of Paris, Paris, 75006, France., Uygun BE; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. basakuygun@mgh.harvard.edu.; Shriners Children's Boston, Boston, MA, 02114, USA. basakuygun@mgh.harvard.edu.
Source: Stem cell reviews and reports [Stem Cell Rev Rep] 2026 May; Vol. 22 (4), pp. 1827-1839. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101752767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE
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  Data: Creating Engineered NAC Flaps Using in Vivo Revascularization: A Proof-Of-Concept Study.
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  Data: <searchLink fieldCode="AU" term="%22Berkane+Y%22">Berkane Y</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. yanis.berkane@chu-rennes.fr.; Shriners Children's Boston, Boston, MA, 02114, USA. yanis.berkane@chu-rennes.fr.; Department of Plastic, Reconstructive and Aesthetic Surgery, CHU de Rennes, University of Rennes, Rennes, 35000, France. yanis.berkane@chu-rennes.fr.; SITI Laboratory, UMR1236, INSERM, Etablissement Francais du Sang, University of Rennes, Rennes, 35000, France. yanis.berkane@chu-rennes.fr.<br /><searchLink fieldCode="AU" term="%22Abaci+A%22">Abaci A</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Ellis+BW%22">Ellis BW</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22van+Dieren+L%22">van Dieren L</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Hendi+E%22">Hendi E</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Oubari+H%22">Oubari H</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Bertheuil+N%22">Bertheuil N</searchLink>; Department of Plastic, Reconstructive and Aesthetic Surgery, CHU de Rennes, University of Rennes, Rennes, 35000, France.; SITI Laboratory, UMR1236, INSERM, Etablissement Francais du Sang, University of Rennes, Rennes, 35000, France.<br /><searchLink fieldCode="AU" term="%22Oganesyan+R%22">Oganesyan R</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Cetrulo+CL+Jr%22">Cetrulo CL Jr</searchLink>; Shriners Children's Boston, Boston, MA, 02114, USA.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA.; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22McCarthy+ME%22">McCarthy ME</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Shriners Children's Boston, Boston, MA, 02114, USA.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of General Surgery, Lahey Hospital and Medical Center, Burlington, MA, 01805, USA.<br /><searchLink fieldCode="AU" term="%22Randolph+MA%22">Randolph MA</searchLink>; Shriners Children's Boston, Boston, MA, 02114, USA.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lellouch+AG%22">Lellouch AG</searchLink>; Shriners Children's Boston, Boston, MA, 02114, USA.; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA.; Division of Plastic and Reconstructive Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Innovative Therapies in Hemostasis, INSERM UMR-S 1140, University of Paris, Paris, 75006, France.<br /><searchLink fieldCode="AU" term="%22Uygun+BE%22">Uygun BE</searchLink>; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. basakuygun@mgh.harvard.edu.; Shriners Children's Boston, Boston, MA, 02114, USA. basakuygun@mgh.harvard.edu.
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