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PAN2 maintains mRNA poly(A) tail homeostasis and regulates translation during spermiogenesis in mice.

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Title: PAN2 maintains mRNA poly(A) tail homeostasis and regulates translation during spermiogenesis in mice.
Authors: Wu X; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China., Wu YK; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China., Jia MY; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China., Niu Z; Laboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Liu J; Laboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Wang WJ; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China., Jiang ZY; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China., Lu F; Laboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. fllu@genetics.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. fllu@genetics.ac.cn., Chen L; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. l_chen@hsc.pku.edu.cn., Liu L; Department of Reproductive Medicine and Genetics Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. liulilingnn@126.com., Fan HY; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. hyfan@zju.edu.cn.
Source: Nature communications [Nat Commun] 2026 Feb 19; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PAN2 maintains mRNA poly(A) tail homeostasis and regulates translation during spermiogenesis in mice.
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  Data: <searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+YK%22">Wu YK</searchLink>; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Jia+MY%22">Jia MY</searchLink>; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Niu+Z%22">Niu Z</searchLink>; Laboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Laboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+WJ%22">Wang WJ</searchLink>; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Jiang+ZY%22">Jiang ZY</searchLink>; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lu+F%22">Lu F</searchLink>; Laboratory of Integrative Physiology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. fllu@genetics.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. fllu@genetics.ac.cn.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. l_chen@hsc.pku.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Reproductive Medicine and Genetics Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. liulilingnn@126.com.<br /><searchLink fieldCode="AU" term="%22Fan+HY%22">Fan HY</searchLink>; Life Sciences Institute, Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. hyfan@zju.edu.cn.
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              Text: 2026 Feb 19
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