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What does BCL-2 do? From new molecular insights to the clinical implications.

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Title: What does BCL-2 do? From new molecular insights to the clinical implications.
Authors: Croce CM; Department of Cancer Biology and Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. Carlo.Croce@osumc.edu., Tait SWG; Cancer Research UK Scotland Institute, Glasgow, UK. Stephen.Tait@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, UK. Stephen.Tait@glasgow.ac.uk., Garcia-Sáez AJ; Max Planck Institute of Biophysics, Frankfurt am Main, Germany. ana.garcia@biophys.mpg.de.; Institute of Genetics, CECAD, University of Cologne, Cologne, Germany. ana.garcia@biophys.mpg.de., Villunger A; Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria. andreas.villunger@i-med.ac.at.; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. andreas.villunger@i-med.ac.at., Letai A; Dana-Farber Cancer Institute, Harvard University, Cambridge, MA, USA. anthony_letai@dfci.harvard.edu., Walter HS; The Ernest and Helen Scott Haematological Research Institute, Department of Genetics, Genomics and Cancer Sciences, University of Leicester, Leicester, UK. hw191@le.ac.uk., Dyer MJS; The Ernest and Helen Scott Haematological Research Institute, Department of Genetics, Genomics and Cancer Sciences, University of Leicester, Leicester, UK. mjsd1@le.ac.uk., Green DR; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA. douglas.green@stjude.org., Shi Y; The Fourth Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College Soochow University, Suzhou, China. yfshi@suda.edu.cn., Melino G; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy. melino@uniroma2.it.
Source: Cell death and differentiation [Cell Death Differ] 2026 Apr; Vol. 33 (4), pp. 673-693. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Croce+CM%22">Croce CM</searchLink>; Department of Cancer Biology and Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. Carlo.Croce@osumc.edu.<br /><searchLink fieldCode="AU" term="%22Tait+SWG%22">Tait SWG</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK. Stephen.Tait@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, UK. Stephen.Tait@glasgow.ac.uk.<br /><searchLink fieldCode="AU" term="%22Garcia-Sáez+AJ%22">Garcia-Sáez AJ</searchLink>; Max Planck Institute of Biophysics, Frankfurt am Main, Germany. ana.garcia@biophys.mpg.de.; Institute of Genetics, CECAD, University of Cologne, Cologne, Germany. ana.garcia@biophys.mpg.de.<br /><searchLink fieldCode="AU" term="%22Villunger+A%22">Villunger A</searchLink>; Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria. andreas.villunger@i-med.ac.at.; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. andreas.villunger@i-med.ac.at.<br /><searchLink fieldCode="AU" term="%22Letai+A%22">Letai A</searchLink>; Dana-Farber Cancer Institute, Harvard University, Cambridge, MA, USA. anthony_letai@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Walter+HS%22">Walter HS</searchLink>; The Ernest and Helen Scott Haematological Research Institute, Department of Genetics, Genomics and Cancer Sciences, University of Leicester, Leicester, UK. hw191@le.ac.uk.<br /><searchLink fieldCode="AU" term="%22Dyer+MJS%22">Dyer MJS</searchLink>; The Ernest and Helen Scott Haematological Research Institute, Department of Genetics, Genomics and Cancer Sciences, University of Leicester, Leicester, UK. mjsd1@le.ac.uk.<br /><searchLink fieldCode="AU" term="%22Green+DR%22">Green DR</searchLink>; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA. douglas.green@stjude.org.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; The Fourth Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College Soochow University, Suzhou, China. yfshi@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Melino+G%22">Melino G</searchLink>; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy. melino@uniroma2.it.
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  Data: <searchLink fieldCode="JN" term="%229437445%22">Cell death and differentiation</searchLink> [Cell Death Differ] 2026 Apr; Vol. 33 (4), pp. 673-693. <i>Date of Electronic Publication: </i>2026 Feb 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9437445 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5403 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213509047%22">13509047 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Differ <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41418-025-01607-3
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              Text: 2026 Apr
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