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The polyamine inhibitor SAM486A increases the efficacy of adagrasib in non-small cell lung cancer cells harboring KRASG12C mutation.

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Title: The polyamine inhibitor SAM486A increases the efficacy of adagrasib in non-small cell lung cancer cells harboring KRASG12C mutation.
Authors: Martin-Martin A; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile., Chipón C; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile., Guzman-Kunstmann C; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile., Guzman-Kunstmann S; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile., Buelvas N; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile., Henríquez C; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile., Vidal F; Unidad Medicina Traslacional, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile., Villarroel-Espindola F; Unidad Medicina Traslacional, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile., Hinz TK; School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Heasley LE; School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., López-Muñoz RA; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile. rodrigo.lopez@uach.cl.
Source: Biological research [Biol Res] 2026 Feb 19; Vol. 59 (1). Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Biomed Central, Ltd Country of Publication: England NLM ID: 9308271 Publication Model: Electronic Cited Medium: Internet ISSN: 0717-6287 (Electronic) Linking ISSN: 07169760 NLM ISO Abbreviation: Biol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The polyamine inhibitor SAM486A increases the efficacy of adagrasib in non-small cell lung cancer cells harboring KRAS<superscript>G12C</superscript> mutation.
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  Data: <searchLink fieldCode="AU" term="%22Martin-Martin+A%22">Martin-Martin A</searchLink>; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile.<br /><searchLink fieldCode="AU" term="%22Chipón+C%22">Chipón C</searchLink>; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile.<br /><searchLink fieldCode="AU" term="%22Guzman-Kunstmann+C%22">Guzman-Kunstmann C</searchLink>; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile.<br /><searchLink fieldCode="AU" term="%22Guzman-Kunstmann+S%22">Guzman-Kunstmann S</searchLink>; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile.<br /><searchLink fieldCode="AU" term="%22Buelvas+N%22">Buelvas N</searchLink>; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile.<br /><searchLink fieldCode="AU" term="%22Henríquez+C%22">Henríquez C</searchLink>; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile.<br /><searchLink fieldCode="AU" term="%22Vidal+F%22">Vidal F</searchLink>; Unidad Medicina Traslacional, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Villarroel-Espindola+F%22">Villarroel-Espindola F</searchLink>; Unidad Medicina Traslacional, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Hinz+TK%22">Hinz TK</searchLink>; School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.<br /><searchLink fieldCode="AU" term="%22Heasley+LE%22">Heasley LE</searchLink>; School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.<br /><searchLink fieldCode="AU" term="%22López-Muñoz+RA%22">López-Muñoz RA</searchLink>; Instituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, PO. 5090000, Valdivia, Chile. rodrigo.lopez@uach.cl.
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  Data: <searchLink fieldCode="JN" term="%229308271%22">Biological research</searchLink> [Biol Res] 2026 Feb 19; Vol. 59 (1). <i>Date of Electronic Publication: </i>2026 Feb 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Biomed+Central%2C+Ltd%22">Biomed Central, Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9308271 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>0717-6287 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207169760%22">07169760 </searchLink><i>NLM ISO Abbreviation: </i>Biol Res <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 19
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