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Immune checkpoint inhibitor-induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling.

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Title: Immune checkpoint inhibitor-induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling.
Authors: Warrick KA; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center and University of Cincinnati , Cincinnati, OH, USA.; Medical Scientist Training Program, University of Cincinnati College of Medicine , Cincinnati, OH, USA.; Division of Molecular Cardiovascular Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Johansen AKZ; Division of Molecular Cardiovascular Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Jiao M; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Linnemann ME; Medical Sciences Undergraduate Program, University of Cincinnati College of Medicine , Cincinnati, OH, USA., Saha I; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Lin SJ; Division of Molecular Cardiovascular Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Vallez CN; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center and University of Cincinnati , Cincinnati, OH, USA.; Medical Scientist Training Program, University of Cincinnati College of Medicine , Cincinnati, OH, USA.; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Hagan T; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Molkentin JD; Division of Molecular Cardiovascular Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Pasare C; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Source: The Journal of experimental medicine [J Exp Med] 2026 Apr 06; Vol. 223 (4). Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: Immune checkpoint inhibitor-induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling.
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  Data: <searchLink fieldCode="AU" term="%22Warrick+KA%22">Warrick KA</searchLink>; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center and University of Cincinnati , Cincinnati, OH, USA.; Medical Scientist Training Program, University of Cincinnati College of Medicine , Cincinnati, OH, USA.; Division of Molecular Cardiovascular Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Johansen+AKZ%22">Johansen AKZ</searchLink>; Division of Molecular Cardiovascular Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Jiao+M%22">Jiao M</searchLink>; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Linnemann+ME%22">Linnemann ME</searchLink>; Medical Sciences Undergraduate Program, University of Cincinnati College of Medicine , Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Saha+I%22">Saha I</searchLink>; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lin+SJ%22">Lin SJ</searchLink>; Division of Molecular Cardiovascular Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Vallez+CN%22">Vallez CN</searchLink>; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center and University of Cincinnati , Cincinnati, OH, USA.; Medical Scientist Training Program, University of Cincinnati College of Medicine , Cincinnati, OH, USA.; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hagan+T%22">Hagan T</searchLink>; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Molkentin+JD%22">Molkentin JD</searchLink>; Division of Molecular Cardiovascular Biology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Pasare+C%22">Pasare C</searchLink>; Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
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  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2026 Apr 06; Vol. 223 (4). <i>Date of Electronic Publication: </i>2026 Feb 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Rockefeller+University+Press%22">Rockefeller University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985109R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1540-9538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221007%22">00221007 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Med <i>Subsets: </i>MEDLINE
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        Value: 10.1084/jem.20251717
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        Text: English
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            – D: 06
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              Text: 2026 Apr 06
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