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Genetic modifiers of APOE-ε4-associated cognitive decline.

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Title: Genetic modifiers of APOE-ε4-associated cognitive decline.
Authors: Contreras AG; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Walters S; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Eissman JM; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Archer DB; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Regelson AN; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Durant A; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Clifton M; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Lee ML; Department of Medicine, University of Washington, Seattle, WA, USA., Choi SE; Department of Medicine, University of Washington, Seattle, WA, USA., Scollard P; Department of Medicine, University of Washington, Seattle, WA, USA., Trittschuh EH; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.; VA Puget Sound Health Care System, GRECC, Seattle, WA, USA., Mez J; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Bush WS; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Naj AC; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Gifford KA; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Bilgel M; Laboratory of Behavioral Neuroscience National Institute on Aging National Institutes of Health, Baltimore, MD, USA., Kuzma AB; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Farrer LA; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Wang LS; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Schellenberg GD; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Haines JL; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Jefferson AL; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Kukull WA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Keene CD; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Saykin AJ; Department of Radiology and Imaging Services, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA., Thompson PM; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Albert MS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Johnson SC; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Engelman CD; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Ferrucci L; Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Sperling RA; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Resnick SM; Laboratory of Behavioral Neuroscience National Institute on Aging National Institutes of Health, Baltimore, MD, USA., Crane PK; Department of Medicine, University of Washington, Seattle, WA, USA., Dumitrescu L; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Hohman TJ; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA. timothy.j.hohman@vumc.org.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. timothy.j.hohman@vumc.org.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), Alzheimer’s Disease Sequencing Project (ADSP)
Source: Nature communications [Nat Commun] 2026 Feb 20; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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