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Clinical and histopathological characterization of metastatic lobular breast cancer: lessons learned from post-mortem tissue donation programs.

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Title: Clinical and histopathological characterization of metastatic lobular breast cancer: lessons learned from post-mortem tissue donation programs.
Authors: Zels G; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Pathology, University Hospitals Leuven, Leuven, Belgium., Van Baelen K; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium., Chang AC; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Pabba A; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium., De Schepper M; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Pathology, University Hospitals Leuven, Leuven, Belgium., Maetens M; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium., Richard F; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium., Van Cauwenberge J; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium., Geukens T; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium., Borremans K; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium., Mahdami A; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium., Nguyen HL; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium., Leduc S; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium., Neven P; Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium., Wildiers H; Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium., Vandecaveye V; Department of Radiology, University Hospitals Leuven, Leuven, Belgium., Dresen R; Department of Radiology, University Hospitals Leuven, Leuven, Belgium., Van Den Bogaert W; Department of Forensic Medicine, University Hospitals Leuven, Leuven, Belgium., Bhargava R; Department of Pathology, University of Pittsburgh School of Medicine, Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA., Bartholow T; Department of Pathology, University of Pittsburgh School of Medicine, Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA., Carleton N; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Cao Y; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Bejing, China., Liu JB; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Wedn A; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Waltermire H; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Cody M; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Miller L; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA., Rosenzweig MQ; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA., Foldi J; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA., Balic M; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA.; National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, PA, USA., Deible C; Department of Radiology, UPMC, Pittsburgh, PA, USA., Hodgdon C; Guiding Researchers and Advocates to Scientific Partnerships (GRASP Cancer), Baltimore, MD, USA., Walker S; Metastatic Breast Cancer Alliance, New York City, Ny, USA; Living Beyond Breast Cancer (LBBC), Bala Cynwyd, PA, USA., Lee AV; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Institute for Precision Medicine, UPMC, Pittsburgh, PA, USA., Oesterreich S; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Floris G; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.; Department of Imaging & Pathology, Laboratory for translational Cell & Tissue Research, Leuven, Belgium., Desmedt C; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium. Christine.desmedt@kuleuven.be.
Source: NPJ breast cancer [NPJ Breast Cancer] 2026 Feb 20; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical and histopathological characterization of metastatic lobular breast cancer: lessons learned from post-mortem tissue donation programs.
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  Data: <searchLink fieldCode="AU" term="%22Zels+G%22">Zels G</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Baelen+K%22">Van Baelen K</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Chang+AC%22">Chang AC</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pabba+A%22">Pabba A</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Schepper+M%22">De Schepper M</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Maetens+M%22">Maetens M</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Richard+F%22">Richard F</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Cauwenberge+J%22">Van Cauwenberge J</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Geukens+T%22">Geukens T</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Borremans+K%22">Borremans K</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Mahdami+A%22">Mahdami A</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Nguyen+HL%22">Nguyen HL</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Leduc+S%22">Leduc S</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Neven+P%22">Neven P</searchLink>; Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Wildiers+H%22">Wildiers H</searchLink>; Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vandecaveye+V%22">Vandecaveye V</searchLink>; Department of Radiology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Dresen+R%22">Dresen R</searchLink>; Department of Radiology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Den+Bogaert+W%22">Van Den Bogaert W</searchLink>; Department of Forensic Medicine, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Bhargava+R%22">Bhargava R</searchLink>; Department of Pathology, University of Pittsburgh School of Medicine, Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bartholow+T%22">Bartholow T</searchLink>; Department of Pathology, University of Pittsburgh School of Medicine, Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Carleton+N%22">Carleton N</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Bejing, China.<br /><searchLink fieldCode="AU" term="%22Liu+JB%22">Liu JB</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wedn+A%22">Wedn A</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Waltermire+H%22">Waltermire H</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cody+M%22">Cody M</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+L%22">Miller L</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rosenzweig+MQ%22">Rosenzweig MQ</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Foldi+J%22">Foldi J</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Balic+M%22">Balic M</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA.; National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Deible+C%22">Deible C</searchLink>; Department of Radiology, UPMC, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hodgdon+C%22">Hodgdon C</searchLink>; Guiding Researchers and Advocates to Scientific Partnerships (GRASP Cancer), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Walker+S%22">Walker S</searchLink>; Metastatic Breast Cancer Alliance, New York City, Ny, USA; Living Beyond Breast Cancer (LBBC), Bala Cynwyd, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+AV%22">Lee AV</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Institute for Precision Medicine, UPMC, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Oesterreich+S%22">Oesterreich S</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Floris+G%22">Floris G</searchLink>; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.; Department of Imaging & Pathology, Laboratory for translational Cell & Tissue Research, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Desmedt+C%22">Desmedt C</searchLink>; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium. Christine.desmedt@kuleuven.be.
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