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Discovery of vasodilatory effects of Na+/H+ exchanger 1 inhibitors to treat vasospastic angina.

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Title: Discovery of vasodilatory effects of Na+/H+ exchanger 1 inhibitors to treat vasospastic angina.
Authors: Dong XF; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.; Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK.; Department of Cardiology, Emergency Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China., Jing XJ; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.; Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, 250012, China., Tang ZY; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, 250012, China., Huang SL; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China., Yin JZ; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China., Chen Y; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China., Guo T; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China., Dong B; Department of Cardiology, Emergency Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China., Li B; Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, China., Li P; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China., Wang SX; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China. shuangxiwang@sdu.edu.cn.; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China. shuangxiwang@sdu.edu.cn., Bai WW; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China. baiwenwu@sdu.edu.cn.; Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan, 250012, China. baiwenwu@sdu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun; Vol. 47 (6), pp. 1594-1604. Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
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  Data: Discovery of vasodilatory effects of Na<superscript>+</superscript>/H<superscript>+</superscript> exchanger 1 inhibitors to treat vasospastic angina.
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  Data: <searchLink fieldCode="AU" term="%22Dong+XF%22">Dong XF</searchLink>; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.; Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK.; Department of Cardiology, Emergency Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.<br /><searchLink fieldCode="AU" term="%22Jing+XJ%22">Jing XJ</searchLink>; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.; Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Tang+ZY%22">Tang ZY</searchLink>; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Huang+SL%22">Huang SL</searchLink>; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Yin+JZ%22">Yin JZ</searchLink>; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Guo+T%22">Guo T</searchLink>; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.<br /><searchLink fieldCode="AU" term="%22Dong+B%22">Dong B</searchLink>; Department of Cardiology, Emergency Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.<br /><searchLink fieldCode="AU" term="%22Wang+SX%22">Wang SX</searchLink>; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China. shuangxiwang@sdu.edu.cn.; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China. shuangxiwang@sdu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Bai+WW%22">Bai WW</searchLink>; State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China. baiwenwu@sdu.edu.cn.; Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan, 250012, China. baiwenwu@sdu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jun; Vol. 47 (6), pp. 1594-1604. <i>Date of Electronic Publication: </i>2026 Feb 20.
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        Value: 10.1038/s41401-025-01734-0
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        Text: English
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