View in EDS HTML Full Text PDF Full Text

ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1.

Saved in:
Bibliographic Details
Title: ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1.
Authors: Janesha UGS; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Ruhuna, Galle, 80000, Sri Lanka., Chiu CT; An Nan Hospital, China Medical University, Tainan, 70955, Taiwan., Tsai MH; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan.; School of Medicine, Chang Gung University College of Medicine, Taoyuan, 33302, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Chang KM; Department of Otolaryngology, Head and Neck Surgery, Pingtung Veterans General Hospital, Pingtung, 90090, Taiwan.; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 83301, Taiwan., Chien CY; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.; Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Huang HS; Department of Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan., Li HY; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Yang YC; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Division of Neurosurgery, Division of Neurosurgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 813414, Taiwan., Lu H; Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Pan CT; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Shiao MS; Research Laboratory Section, Offices of Health Science Research, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand., Lin YH; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. yhlin0619@vghks.gov.tw.; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 83301, Taiwan. yhlin0619@vghks.gov.tw.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan. yhlin0619@vghks.gov.tw.; School of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan. yhlin0619@vghks.gov.tw., Shiue YL; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw.; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw.; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Feb 21; Vol. 83 (1). Date of Electronic Publication: 2026 Feb 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41721860
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Janesha+UGS%22">Janesha UGS</searchLink>; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Ruhuna, Galle, 80000, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Chiu+CT%22">Chiu CT</searchLink>; An Nan Hospital, China Medical University, Tainan, 70955, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+MH%22">Tsai MH</searchLink>; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan.; School of Medicine, Chang Gung University College of Medicine, Taoyuan, 33302, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+KM%22">Chang KM</searchLink>; Department of Otolaryngology, Head and Neck Surgery, Pingtung Veterans General Hospital, Pingtung, 90090, Taiwan.; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 83301, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+CY%22">Chien CY</searchLink>; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.; Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+HS%22">Huang HS</searchLink>; Department of Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+HY%22">Li HY</searchLink>; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+YC%22">Yang YC</searchLink>; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Division of Neurosurgery, Division of Neurosurgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 813414, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+H%22">Lu H</searchLink>; Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Pan+CT%22">Pan CT</searchLink>; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shiao+MS%22">Shiao MS</searchLink>; Research Laboratory Section, Offices of Health Science Research, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.<br /><searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. yhlin0619@vghks.gov.tw.; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 83301, Taiwan. yhlin0619@vghks.gov.tw.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan. yhlin0619@vghks.gov.tw.; School of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan. yhlin0619@vghks.gov.tw.<br /><searchLink fieldCode="AU" term="%22Shiue+YL%22">Shiue YL</searchLink>; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw.; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw.; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Feb 21; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Feb 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41721860
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00018-025-06027-7
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Janesha UGS
      – PersonEntity:
          Name:
            NameFull: Chiu CT
      – PersonEntity:
          Name:
            NameFull: Tsai MH
      – PersonEntity:
          Name:
            NameFull: Chang KM
      – PersonEntity:
          Name:
            NameFull: Chien CY
      – PersonEntity:
          Name:
            NameFull: Huang HS
      – PersonEntity:
          Name:
            NameFull: Li HY
      – PersonEntity:
          Name:
            NameFull: Yang YC
      – PersonEntity:
          Name:
            NameFull: Lu H
      – PersonEntity:
          Name:
            NameFull: Pan CT
      – PersonEntity:
          Name:
            NameFull: Shiao MS
      – PersonEntity:
          Name:
            NameFull: Lin YH
      – PersonEntity:
          Name:
            NameFull: Shiue YL
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 02
              Text: 2026 Feb 21
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1420-9071
          Numbering:
            – Type: volume
              Value: 83
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Cellular and molecular life sciences : CMLS
              Type: main
ResultId 1