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FGTI-2734 prevents ERK-mediated resistance and enhances MRTX1133 efficacy in KRAS G12D pancreatic cancer.

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Title: FGTI-2734 prevents ERK-mediated resistance and enhances MRTX1133 efficacy in KRAS G12D pancreatic cancer.
Authors: Ghosh D; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA., Kazi A; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA., Vasiyani HKK; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA., Vudatha V; Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA., Lecomte N; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Iacobuzio-Donahue C; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Trevino J; Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA., Sebti SM; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA. Electronic address: Said.Sebti@vcuhealth.org.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Mar 11; Vol. 236, pp. 116255. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: FGTI-2734 prevents ERK-mediated resistance and enhances MRTX1133 efficacy in KRAS G12D pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ghosh+D%22">Ghosh D</searchLink>; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA.<br /><searchLink fieldCode="AU" term="%22Kazi+A%22">Kazi A</searchLink>; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA.<br /><searchLink fieldCode="AU" term="%22Vasiyani+HKK%22">Vasiyani HKK</searchLink>; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA.<br /><searchLink fieldCode="AU" term="%22Vudatha+V%22">Vudatha V</searchLink>; Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA.<br /><searchLink fieldCode="AU" term="%22Lecomte+N%22">Lecomte N</searchLink>; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Iacobuzio-Donahue+C%22">Iacobuzio-Donahue C</searchLink>; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Trevino+J%22">Trevino J</searchLink>; Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA.<br /><searchLink fieldCode="AU" term="%22Sebti+SM%22">Sebti SM</searchLink>; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, USA. Electronic address: Said.Sebti@vcuhealth.org.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Mar 11; Vol. 236, pp. 116255. <i>Date of Electronic Publication: </i>2026 Feb 03.
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