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Identifying microbial protease allergens through protein language model-guided homology.

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Title: Identifying microbial protease allergens through protein language model-guided homology.
Authors: Thurimella K; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Wu E; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Li C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Graham DB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Owens RM; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK., Plichta DR; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: damian@broadinstitute.org., Sokol CL; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: clsokol@mgh.harvard.edu., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: xavier@molbio.mgh.harvard.edu., Bacallado S; Department of Pure Mathematics and Mathematical Statistics, University of Cambridge, Cambridge CB3 0WB, UK. Electronic address: sb2116@cam.ac.uk.
Source: Cell systems [Cell Syst] 2026 Mar 18; Vol. 17 (3), pp. 101510. Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101656080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4720 (Electronic) Linking ISSN: 24054712 NLM ISO Abbreviation: Cell Syst Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Thurimella+K%22">Thurimella K</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Wu+E%22">Wu E</searchLink>; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Graham+DB%22">Graham DB</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Owens+RM%22">Owens RM</searchLink>; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK.<br /><searchLink fieldCode="AU" term="%22Plichta+DR%22">Plichta DR</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: damian@broadinstitute.org.<br /><searchLink fieldCode="AU" term="%22Sokol+CL%22">Sokol CL</searchLink>; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: clsokol@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Xavier+RJ%22">Xavier RJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: xavier@molbio.mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Bacallado+S%22">Bacallado S</searchLink>; Department of Pure Mathematics and Mathematical Statistics, University of Cambridge, Cambridge CB3 0WB, UK. Electronic address: sb2116@cam.ac.uk.
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              Text: 2026 Mar 18
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