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FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.

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Title: FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
Authors: Lu W; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Jiang M; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Zhuang J; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Song J; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Zhou C; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Zhou Y; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Zhu Z; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Wu A; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. aiminwu@wmu.edu.cn., Sheng S; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. shengsunren82330@126.com., Zhu S; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. sipinzhu@163.com., Wang Z; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. wzhouguang@gmail.com.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. wzhouguang@gmail.com.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. wzhouguang@gmail.com.
Source: Journal of neuroinflammation [J Neuroinflammation] 2026 Feb 23; Vol. 23 (1). Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41724991
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
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  Data: <searchLink fieldCode="AU" term="%22Lu+W%22">Lu W</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Jiang+M%22">Jiang M</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+J%22">Zhuang J</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Song+J%22">Song J</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.<br /><searchLink fieldCode="AU" term="%22Wu+A%22">Wu A</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. aiminwu@wmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sheng+S%22">Sheng S</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. shengsunren82330@126.com.<br /><searchLink fieldCode="AU" term="%22Zhu+S%22">Zhu S</searchLink>; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. sipinzhu@163.com.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. wzhouguang@gmail.com.; State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. wzhouguang@gmail.com.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. wzhouguang@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101222974%22">Journal of neuroinflammation</searchLink> [J Neuroinflammation] 2026 Feb 23; Vol. 23 (1). <i>Date of Electronic Publication: </i>2026 Feb 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101222974 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1742-2094 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217422094%22">17422094 </searchLink><i>NLM ISO Abbreviation: </i>J Neuroinflammation <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41724991
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1186/s12974-026-03743-0
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      – Code: eng
        Text: English
    Titles:
      – TitleFull: FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
        Type: main
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            NameFull: Lu W
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              Text: 2026 Feb 23
              Type: published
              Y: 2026
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              Value: 1742-2094
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