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The North American Prodromal Synucleinopathy study: protocol for a multi-site, longitudinal, observational study of idiopathic/isolated rapid eye movement sleep behavior disorder.

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Title: The North American Prodromal Synucleinopathy study: protocol for a multi-site, longitudinal, observational study of idiopathic/isolated rapid eye movement sleep behavior disorder.
Authors: Lim MM; Research Service, VA Portland Health Care System, Portland, OR, United States.; Department of Neurology, Oregon Health and Science University, Portland, OR, United States., Neilson LE; Research Service, VA Portland Health Care System, Portland, OR, United States.; Department of Neurology, Oregon Health and Science University, Portland, OR, United States.; Department of Neurology, University of Iowa, Iowa City, IA, United States., Elliott JE; Research Service, VA Portland Health Care System, Portland, OR, United States., Hoang-Dang B; Department of Neurology, Oregon Health and Science University, Portland, OR, United States., Locke JR; Research Service, VA Portland Health Care System, Portland, OR, United States.; Department of Neurology, Oregon Health and Science University, Portland, OR, United States., Cunningham H; Department of Neurology, Oregon Health and Science University, Portland, OR, United States., Brewer J; Department of Neurology, Oregon Health and Science University, Portland, OR, United States., Dennis L; Research Service, VA Portland Health Care System, Portland, OR, United States.; Department of Neurology, Oregon Health and Science University, Portland, OR, United States., Dovek L; Research Service, VA Portland Health Care System, Portland, OR, United States.; Department of Neurology, Oregon Health and Science University, Portland, OR, United States., Pelletier A; Department of Neurology and Neurosurgery, The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal QC, Canada.; Research Institute of the Montreal University Health Centre, Montreal QC, Canada.; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM, Montreal, QC, Canada., St Louis EK; Department of Neurology, Mayo Clinic, Rochester, MN, United States.; Department of Medicine, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN, United States., McCarter SJ; Department of Neurology, Mayo Clinic, Rochester, MN, United States., Miyagawa T; Department of Neurology, Mayo Clinic, Rochester, MN, United States., Davis AA; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, United States., McLeland JS; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, United States., Criswell S; Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States., Howell MJ; Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, United States., Schenck CH; Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, United States., Avidan AY; Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States., Trotti LM; Department of Neurology, Emory University, Atlanta, GA, United States., Bliwise DL; Department of Neurology, Emory University, Atlanta, GA, United States., Huddleston DE; Department of Neurology, Emory University, Atlanta, GA, United States., Videnovic A; Department of Neurology, Mass General Brigham, Boston, MA, United States., Miglis MG; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, United States.; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, United States., Sum-Ping O; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, United States., Lee-Iannotti JK; Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States.; Department of Neurology, University of Arizona College of Medicine, Phoenix, AZ, United States., Shprecher DR; Department of Neurology, Banner Sun Health Research Institute, Sun City, AZ, United States., Duff K; Department of Neurology, Oregon Health and Science University, Portland, OR, United States., Ferman TJ; Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, United States., Campbell MC; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, United States.; Department of Radiology, Washington University School of Medicine, Saint Louis, MO, United States., Fields JA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States., Gagnon JF; Department of Psychology, Université du Québec à Montréal, Montreal QC, Canada., Kotzbauer P; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, United States., Singer W; Department of Neurology, Mayo Clinic, Rochester, MN, United States., Gan-Or Z; Department of Neurology and Neurosurgery, The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal QC, Canada., Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States., Kantarci K; Department of Radiology, Mayo Clinic, Rochester, MN, United States., Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, MN, United States., Hu XP; Center for Advanced Neuroimaging, Department of Bioengineering, University of California, Riverside, CA, United States., Ehgoetz Martens KA; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada., Hu MT; Nuffield Department of Clinical Neurosciences, Division of Neurology, University of Oxford, Oxford, United Kingdom., Xiong C; Center for Biostatistics and Data Science, Washington University School of Medicine, Saint Louis, MO, United States., Postuma RB; Department of Neurology and Neurosurgery, The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal QC, Canada., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, United States., Ju YS; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, United States.; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, United States.; Center on Biological Rhythms and Sleep, Washington University School of Medicine, Saint Louis, MO, United States.
Corporate Authors: NAPS Consortium for RBD
Source: Sleep advances : a journal of the Sleep Research Society [Sleep Adv] 2026 Jan 19; Vol. 7 (1), pp. zpag007. Date of Electronic Publication: 2026 Jan 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Sleep Research Society Country of Publication: United States NLM ID: 101774029 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-5012 (Electronic) Linking ISSN: 26325012 NLM ISO Abbreviation: Sleep Adv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The North American Prodromal Synucleinopathy study: protocol for a multi-site, longitudinal, observational study of idiopathic/isolated rapid eye movement sleep behavior disorder.
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  Data: <searchLink fieldCode="AU" term="%22Lim+MM%22">Lim MM</searchLink>; Research Service, VA Portland Health Care System, Portland, OR, United States.; Department of Neurology, Oregon Health and Science University, Portland, OR, United States.<br /><searchLink fieldCode="AU" term="%22Neilson+LE%22">Neilson LE</searchLink>; Research Service, VA Portland Health Care System, Portland, OR, United States.; Department of Neurology, Oregon Health and Science University, Portland, OR, United States.; Department of Neurology, University of Iowa, Iowa City, IA, United States.<br /><searchLink fieldCode="AU" term="%22Elliott+JE%22">Elliott JE</searchLink>; Research Service, VA Portland Health Care System, Portland, OR, United States.<br /><searchLink fieldCode="AU" term="%22Hoang-Dang+B%22">Hoang-Dang B</searchLink>; Department of Neurology, Oregon Health and Science University, Portland, OR, United States.<br /><searchLink fieldCode="AU" term="%22Locke+JR%22">Locke JR</searchLink>; Research Service, VA Portland Health Care System, Portland, OR, United States.; 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Department of Neurology and Neurosurgery, The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal QC, Canada.; Research Institute of the Montreal University Health Centre, Montreal QC, Canada.; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22St+Louis+EK%22">St Louis EK</searchLink>; Department of Neurology, Mayo Clinic, Rochester, MN, United States.; Department of Medicine, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22McCarter+SJ%22">McCarter SJ</searchLink>; Department of Neurology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Miyagawa+T%22">Miyagawa T</searchLink>; Department of Neurology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Davis+AA%22">Davis AA</searchLink>; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, United States.<br /><searchLink fieldCode="AU" term="%22McLeland+JS%22">McLeland JS</searchLink>; 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Department of Neurology, University of Arizona College of Medicine, Phoenix, AZ, United States.<br /><searchLink fieldCode="AU" term="%22Shprecher+DR%22">Shprecher DR</searchLink>; Department of Neurology, Banner Sun Health Research Institute, Sun City, AZ, United States.<br /><searchLink fieldCode="AU" term="%22Duff+K%22">Duff K</searchLink>; Department of Neurology, Oregon Health and Science University, Portland, OR, United States.<br /><searchLink fieldCode="AU" term="%22Ferman+TJ%22">Ferman TJ</searchLink>; Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Campbell+MC%22">Campbell MC</searchLink>; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, United States.; Department of Radiology, Washington University School of Medicine, Saint Louis, MO, United States.<br /><searchLink fieldCode="AU" term="%22Fields+JA%22">Fields JA</searchLink>; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Gagnon+JF%22">Gagnon JF</searchLink>; 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