Wnt-dependent spatiotemporal reprogramming of bone marrow niches drives fibrosis.

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Title: Wnt-dependent spatiotemporal reprogramming of bone marrow niches drives fibrosis.
Authors: Banjanin B; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands., Nagai J; Institute for Computational Genomics, Faculty of Medicine RWTH Aachen University Aachen Germany., Mun Y; Department of Medical Oncology and Hematology University Hospital Zurich Zürich Switzerland., Fuchs S; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands., Snoeren I; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands., Boers J; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands., Segura MLRT; Institute for Computational Genomics, Faculty of Medicine RWTH Aachen University Aachen Germany., Mora HT; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands., Galyga AK; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.; Department of Cell and Tumor Biology, Faculty of Medicine RWTH Aachen University Aachen Germany., Benabid A; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.; Department of Cell and Tumor Biology, Faculty of Medicine RWTH Aachen University Aachen Germany., Sarkis R; Laboratory of Regenerative Hematopoiesis University of Lausanne Lausanne Switzerland., Naveiras O; Laboratory of Regenerative Hematopoiesis University of Lausanne Lausanne Switzerland., Rizk M; Department of Orthodontics, Dental Clinic RWTH Aachen University Aachen Germany., Wolf M; Department of Orthodontics, Dental Clinic RWTH Aachen University Aachen Germany., Craveiro RB; Department of Orthodontics, Dental Clinic RWTH Aachen University Aachen Germany., Peisker F; Department of Medicine II (Nephrology, Rheumatology, Immunology and Hypertension), Faculty of Medicine RWTH Aachen University Aachen Germany., Stalmann U; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands., Pritchard JE; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.; Department of Cell and Tumor Biology, Faculty of Medicine RWTH Aachen University Aachen Germany., Ryou H; Department of Cellular Pathology, John Radcliffe Hospital, Oxford University NHS Foundation Trust, and Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine John Radcliffe Hospital Oxford United Kingdom., Alham NK; Department of Cellular Pathology, John Radcliffe Hospital, Oxford University NHS Foundation Trust, and Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine John Radcliffe Hospital Oxford United Kingdom., Weiler M; Department of Experimental Molecular Imaging, Faculty of Medicine RWTH Aachen University Aachen Germany., Kiessling F; Department of Experimental Molecular Imaging, Faculty of Medicine RWTH Aachen University Aachen Germany., Lammers T; Department of Experimental Molecular Imaging, Faculty of Medicine RWTH Aachen University Aachen Germany., Migliaccio AR; Altius Institute for Biomedical Sciences Seattle Washington United States., Sivaraj KK; Department of Tissue Morphogenesis Max Planck Institute for Molecular Biomedicine Münster Germany., Adams RH; Department of Tissue Morphogenesis Max Planck Institute for Molecular Biomedicine Münster Germany., Bindels E; Department of Hematology Erasmus MC Cancer Institute Rotterdam The Netherlands., Gribnau J; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands., Royston D; Department of Cellular Pathology, John Radcliffe Hospital, Oxford University NHS Foundation Trust, and Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine John Radcliffe Hospital Oxford United Kingdom., Gleitz HFE; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands., Kramann R; Department of Medicine II (Nephrology, Rheumatology, Immunology and Hypertension), Faculty of Medicine RWTH Aachen University Aachen Germany., Nombela-Arrieta C; Department of Medical Oncology and Hematology University Hospital Zurich Zürich Switzerland., Costa IG; Institute for Computational Genomics, Faculty of Medicine RWTH Aachen University Aachen Germany., Schneider RK; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.; Department of Cell and Tumor Biology, Faculty of Medicine RWTH Aachen University Aachen Germany.
Source: HemaSphere [Hemasphere] 2026 Feb 20; Vol. 10 (2), pp. e70309. Date of Electronic Publication: 2026 Feb 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE
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  Data: Wnt-dependent spatiotemporal reprogramming of bone marrow niches drives fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Banjanin+B%22">Banjanin B</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nagai+J%22">Nagai J</searchLink>; Institute for Computational Genomics, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Mun+Y%22">Mun Y</searchLink>; Department of Medical Oncology and Hematology University Hospital Zurich Zürich Switzerland.<br /><searchLink fieldCode="AU" term="%22Fuchs+S%22">Fuchs S</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Snoeren+I%22">Snoeren I</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boers+J%22">Boers J</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Segura+MLRT%22">Segura MLRT</searchLink>; Institute for Computational Genomics, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Mora+HT%22">Mora HT</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Galyga+AK%22">Galyga AK</searchLink>; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.; Department of Cell and Tumor Biology, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Benabid+A%22">Benabid A</searchLink>; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.; Department of Cell and Tumor Biology, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Sarkis+R%22">Sarkis R</searchLink>; Laboratory of Regenerative Hematopoiesis University of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Naveiras+O%22">Naveiras O</searchLink>; Laboratory of Regenerative Hematopoiesis University of Lausanne Lausanne Switzerland.<br /><searchLink fieldCode="AU" term="%22Rizk+M%22">Rizk M</searchLink>; Department of Orthodontics, Dental Clinic RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+M%22">Wolf M</searchLink>; Department of Orthodontics, Dental Clinic RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Craveiro+RB%22">Craveiro RB</searchLink>; Department of Orthodontics, Dental Clinic RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Peisker+F%22">Peisker F</searchLink>; Department of Medicine II (Nephrology, Rheumatology, Immunology and Hypertension), Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Stalmann+U%22">Stalmann U</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pritchard+JE%22">Pritchard JE</searchLink>; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.; Department of Cell and Tumor Biology, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Ryou+H%22">Ryou H</searchLink>; Department of Cellular Pathology, John Radcliffe Hospital, Oxford University NHS Foundation Trust, and Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine John Radcliffe Hospital Oxford United Kingdom.<br /><searchLink fieldCode="AU" term="%22Alham+NK%22">Alham NK</searchLink>; Department of Cellular Pathology, John Radcliffe Hospital, Oxford University NHS Foundation Trust, and Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine John Radcliffe Hospital Oxford United Kingdom.<br /><searchLink fieldCode="AU" term="%22Weiler+M%22">Weiler M</searchLink>; Department of Experimental Molecular Imaging, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Kiessling+F%22">Kiessling F</searchLink>; Department of Experimental Molecular Imaging, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Lammers+T%22">Lammers T</searchLink>; Department of Experimental Molecular Imaging, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Migliaccio+AR%22">Migliaccio AR</searchLink>; Altius Institute for Biomedical Sciences Seattle Washington United States.<br /><searchLink fieldCode="AU" term="%22Sivaraj+KK%22">Sivaraj KK</searchLink>; Department of Tissue Morphogenesis Max Planck Institute for Molecular Biomedicine Münster Germany.<br /><searchLink fieldCode="AU" term="%22Adams+RH%22">Adams RH</searchLink>; Department of Tissue Morphogenesis Max Planck Institute for Molecular Biomedicine Münster Germany.<br /><searchLink fieldCode="AU" term="%22Bindels+E%22">Bindels E</searchLink>; Department of Hematology Erasmus MC Cancer Institute Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gribnau+J%22">Gribnau J</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Royston+D%22">Royston D</searchLink>; Department of Cellular Pathology, John Radcliffe Hospital, Oxford University NHS Foundation Trust, and Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine John Radcliffe Hospital Oxford United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gleitz+HFE%22">Gleitz HFE</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kramann+R%22">Kramann R</searchLink>; Department of Medicine II (Nephrology, Rheumatology, Immunology and Hypertension), Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Nombela-Arrieta+C%22">Nombela-Arrieta C</searchLink>; Department of Medical Oncology and Hematology University Hospital Zurich Zürich Switzerland.<br /><searchLink fieldCode="AU" term="%22Costa+IG%22">Costa IG</searchLink>; Institute for Computational Genomics, Faculty of Medicine RWTH Aachen University Aachen Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+RK%22">Schneider RK</searchLink>; Department of Developmental Biology Erasmus Medical Center Rotterdam The Netherlands.; Oncode Institute, Erasmus Medical Center Rotterdam The Netherlands.; Department of Cell and Tumor Biology, Faculty of Medicine RWTH Aachen University Aachen Germany.
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