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Multiplexed high-content imaging uncovers morphological diversity of lymphocyte activation and dysfunction.

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Title: Multiplexed high-content imaging uncovers morphological diversity of lymphocyte activation and dysfunction.
Authors: Matte JC; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Bakker OB; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Ohl MA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Cisternino F; Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy., Manrique-Rincón AJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Husmann A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Lichou F; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Li T; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Kwakwa K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Speak AO; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK., Glastonbury CA; Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy., Bayraktar O; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Jones CP; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK., Claussnitzer M; Broad Institute, 75 Ames Street, Broad Institute of MIT and Harvard, 02142 Cambridge US.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Center for Genomic Medicine, 185 Cambridge St, Boston, MA 02114 USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Trynka G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.; Open Targets, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 11. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Multiplexed high-content imaging uncovers morphological diversity of lymphocyte activation and dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Matte+JC%22">Matte JC</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Bakker+OB%22">Bakker OB</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Ohl+MA%22">Ohl MA</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Cisternino+F%22">Cisternino F</searchLink>; Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Manrique-Rincón+AJ%22">Manrique-Rincón AJ</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Husmann+A%22">Husmann A</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Lichou+F%22">Lichou F</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Kwakwa+K%22">Kwakwa K</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Speak+AO%22">Speak AO</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Glastonbury+CA%22">Glastonbury CA</searchLink>; Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bayraktar+O%22">Bayraktar O</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Jones+CP%22">Jones CP</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.<br /><searchLink fieldCode="AU" term="%22Claussnitzer+M%22">Claussnitzer M</searchLink>; Broad Institute, 75 Ames Street, Broad Institute of MIT and Harvard, 02142 Cambridge US.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Center for Genomic Medicine, 185 Cambridge St, Boston, MA 02114 USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Trynka+G%22">Trynka G</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.; Open Targets, Wellcome Genome Campus, Hinxton, CB10 1RQ, UK.
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              Text: 2026 Feb 11
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