Emergence and antigenic characterisation of influenza A(H3N2) viruses with hemagglutinin substitutions N158K and K189R during the 2024/25 influenza season.

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Title: Emergence and antigenic characterisation of influenza A(H3N2) viruses with hemagglutinin substitutions N158K and K189R during the 2024/25 influenza season.
Authors: Koel B; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands., Byrne AM; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom., Turner S; Center for Pathogen Evolution, University of Cambridge, Cambridge, United Kingdom., James S; Center for Pathogen Evolution, University of Cambridge, Cambridge, United Kingdom., Harvey R; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom., Galiano M; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom., Carr C; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom., Lexmond P; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands., Pronk M; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands., Liang R; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands., Boons GJ; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.; Complex Carbohydrate Research Center, Department of Chemistry, Athens, USA.; Center for Influenza Disease and Emergence Response, University of Georgia, Athens, USA.; Department of Chemistry, University of Georgia, Athens, USA., de Vries RP; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands., Eggink D; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., Lewis N; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom., Smith D; Center for Pathogen Evolution, University of Cambridge, Cambridge, United Kingdom., Meijer A; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., Fouchier R; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 10. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Emergence and antigenic characterisation of influenza A(H3N2) viruses with hemagglutinin substitutions N158K and K189R during the 2024/25 influenza season.
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  Data: <searchLink fieldCode="AU" term="%22Koel+B%22">Koel B</searchLink>; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Byrne+AM%22">Byrne AM</searchLink>; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Turner+S%22">Turner S</searchLink>; Center for Pathogen Evolution, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22James+S%22">James S</searchLink>; Center for Pathogen Evolution, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harvey+R%22">Harvey R</searchLink>; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Galiano+M%22">Galiano M</searchLink>; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Carr+C%22">Carr C</searchLink>; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lexmond+P%22">Lexmond P</searchLink>; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pronk+M%22">Pronk M</searchLink>; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Liang+R%22">Liang R</searchLink>; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boons+GJ%22">Boons GJ</searchLink>; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.; Complex Carbohydrate Research Center, Department of Chemistry, Athens, USA.; Center for Influenza Disease and Emergence Response, University of Georgia, Athens, USA.; Department of Chemistry, University of Georgia, Athens, USA.<br /><searchLink fieldCode="AU" term="%22de+Vries+RP%22">de Vries RP</searchLink>; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Eggink+D%22">Eggink D</searchLink>; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lewis+N%22">Lewis N</searchLink>; WHO Collaborating Centre for Reference and Research on Influenza, Worldwide Influenza Centre, the Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Smith+D%22">Smith D</searchLink>; Center for Pathogen Evolution, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Meijer+A%22">Meijer A</searchLink>; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fouchier+R%22">Fouchier R</searchLink>; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
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