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Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease.

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Title: Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease.
Authors: Ding DY; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; These authors contributed equally: Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen., Bot VA; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Graduate Program in Bioengineering, Stanford University, Stanford, CA, USA.; These authors contributed equally: Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen., Chen KL; Divisions of Hematology and Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; These authors contributed equally: Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen., Groves J; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Pálovics R; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Masuda D; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Management Science and Engineering, Stanford University, Stanford, CA, USA., Farinas A; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Graduate Program in Neuroscience, Stanford University, Stanford, CA, USA., Oh HS; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Brain and Body Research Center of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wagner V; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Lu N; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Cruchaga C; Department of Psychiatry, Washington University, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, USA., Isakova A; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA., Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK., Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Corporate Authors: Global Neurodegeneration Proteomics Consortium (GNPC)
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 12. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ding+DY%22">Ding DY</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; These authors contributed equally: Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen.<br /><searchLink fieldCode="AU" term="%22Bot+VA%22">Bot VA</searchLink>; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Graduate Program in Bioengineering, Stanford University, Stanford, CA, USA.; These authors contributed equally: Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen.<br /><searchLink fieldCode="AU" term="%22Chen+KL%22">Chen KL</searchLink>; Divisions of Hematology and Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; These authors contributed equally: Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen.<br /><searchLink fieldCode="AU" term="%22Groves+J%22">Groves J</searchLink>; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Pálovics+R%22">Pálovics R</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Masuda+D%22">Masuda D</searchLink>; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Management Science and Engineering, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Farinas+A%22">Farinas A</searchLink>; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Graduate Program in Neuroscience, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Oh+HS%22">Oh HS</searchLink>; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Brain and Body Research Center of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wagner+V%22">Wagner V</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+N%22">Lu N</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Isakova+A%22">Isakova A</searchLink>; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schott+JM%22">Schott JM</searchLink>; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Wyss-Coray+T%22">Wyss-Coray T</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
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