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Blinatumomab-driven T-cell activation in αβ and γδ T-cell subsets: insights from in vitro assays.

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Title: Blinatumomab-driven T-cell activation in αβ and γδ T-cell subsets: insights from in vitro assays.
Authors: Kelm M; Medical Department II, Hematology and Oncology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Nasr N; Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Bendig S; Medical Department II, Hematology and Oncology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.; Clinical Research Unit Towards a Cure for Adults and Children with Acute Lymphoblastic Leukemia (CATCH ALL) (KFO 5010), Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Kiel, Germany.; University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, Kiel, Germany., Kabelitz D; Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Lustig M; Clinical Research Unit Towards a Cure for Adults and Children with Acute Lymphoblastic Leukemia (CATCH ALL) (KFO 5010), Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Kiel, Germany.; University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, Kiel, Germany.; Medical Department II, Division of Stem Cell Transplantation and Cellular Immunotherapies, University Hospital Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany., Trautmann H; Medical Department II, Hematology and Oncology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Laqua A; Medical Department II, Hematology and Oncology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Peters C; Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Wesch D; Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Oberg HH; Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Janssen O; Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Valerius T; Clinical Research Unit Towards a Cure for Adults and Children with Acute Lymphoblastic Leukemia (CATCH ALL) (KFO 5010), Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Kiel, Germany.; University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, Kiel, Germany.; Medical Department II, Division of Stem Cell Transplantation and Cellular Immunotherapies, University Hospital Schleswig-Holstein and Christian-Albrechts-University of Kiel, Kiel, Germany., Baldus CD; Medical Department II, Hematology and Oncology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.; Clinical Research Unit Towards a Cure for Adults and Children with Acute Lymphoblastic Leukemia (CATCH ALL) (KFO 5010), Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Kiel, Germany.; University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, Kiel, Germany., Scheffold A; Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.; Clinical Research Unit Towards a Cure for Adults and Children with Acute Lymphoblastic Leukemia (CATCH ALL) (KFO 5010), Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Kiel, Germany.; Technische Universität Berlin, Institute for Biotechnology, Berlin, Germany., Brüggemann M; Medical Department II, Hematology and Oncology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.; Clinical Research Unit Towards a Cure for Adults and Children with Acute Lymphoblastic Leukemia (CATCH ALL) (KFO 5010), Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Kiel, Germany.; University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, Kiel, Germany., Chitadze G; Medical Department II, Hematology and Oncology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.; Clinical Research Unit Towards a Cure for Adults and Children with Acute Lymphoblastic Leukemia (CATCH ALL) (KFO 5010), Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Kiel, Germany.; University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, Kiel, Germany.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 06; Vol. 17, pp. 1739493. Date of Electronic Publication: 2026 Feb 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1739493